Researchers at Nanjing University, China, found new epigenetic markers for colorectal cancer which may offer a new approach for treatment.
Epigenetic alterations leading to colorectal carcinogenesis are thought to hold great promise for the development of novel, minimally invasive molecular biomarkers.
Scientists at the State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, China, have demonstrated that heterochromatin protein HP1γ was critical for CRC cell proliferation and could be specially regulated by miR-30a at the protein level.
"These studies have improved the chances that epigenetic biomarkers will find a place in the clinical practices of screening, early diagnosis, prognosis, therapeutic choice and recurrence surveillance for CRC patients." says Professor Quan Zhao, who is one of the principal investigators at School of Life Sciences, Nanjing University, China.
In the future Professor Zhao and his collaborators want to further investigate the role of these new markers in individual steps of invasion-metastasis cascade of CRC.
Key findings included:
Materials provided by Nanjing University School of Life Sciences. Note: Content may be edited for style and length.
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