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'Alarm clock' of a leukemia-causing oncogene identified

Date:
October 8, 2015
Source:
IDIBELL-Bellvitge Biomedical Research Institute
Summary:
Mutations in DNMT3A gene cause MEIS1 activacion, triggering leukemia, a research team demonstrates.
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New research shows how a mutation in a gene results the activation of a gene that triggers leukemia.

"Recently it has been discovered the existence of mutations in the DNMT3A gene in leukemia. It seemed that history stopped here. But this gene is responsible for silencing other genes that should not be active in the cell; so we wonder which DNA sequence was being "awakened" by this mutation in leukemias" explained Manel Esteller, director of the study.

"By analyzing the entire genome of leukemia cells carrying the mutation, we realized that the activated target gene was called oncogene MEIS1. This is a powerful gene inducing acute myeloid leukemia which its proleucémica function was known, but not as it gets underway. The mutation of another gene explains it"says the researcher.

"We can imagine it as a house of cards. If you remove the card from the bottom row (DNMT3A) just falling all upper layers, such as oncogene MEIS1. The finding, in addition to its usefulness in predicting patients with poor prognosis leukemias, suggests that this subtype of leukemia may be sensitive to drugs that have as target the two genes studied".


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Materials provided by IDIBELL-Bellvitge Biomedical Research Institute. Note: Content may be edited for style and length.


Journal Reference:

  1. H J Ferreira, H Heyn, M Vizoso, C Moutinho, E Vidal, A Gomez, A Martínez-Cardús, L Simó-Riudalbas, S Moran, E Jost, M Esteller. DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene, 2015; DOI: 10.1038/onc.2015.359

Cite This Page:

IDIBELL-Bellvitge Biomedical Research Institute. "'Alarm clock' of a leukemia-causing oncogene identified." ScienceDaily. ScienceDaily, 8 October 2015. <www.sciencedaily.com/releases/2015/10/151008110438.htm>.
IDIBELL-Bellvitge Biomedical Research Institute. (2015, October 8). 'Alarm clock' of a leukemia-causing oncogene identified. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/10/151008110438.htm
IDIBELL-Bellvitge Biomedical Research Institute. "'Alarm clock' of a leukemia-causing oncogene identified." ScienceDaily. www.sciencedaily.com/releases/2015/10/151008110438.htm (accessed May 24, 2017).

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