The prevalence of chronic kidney disease (CKD) is on the rise, with more than 20 million Americans burdened by the disease. Diabetes and hypertension are common risk factors for CKD; however, certain medications can also play a role. Two new studies show that increased use of proton pump inhibitors (PPIs), medications that treat reflux and stomach ulcers, may be contributing to the CKD epidemic.

In one study, Benjamin Lazarus, MBBS (Johns Hopkins University) and his colleagues followed 10,482 adults with normal kidney function from 1996 to 2011. They found that PPI users were between 20% and 50% more likely to develop CKD than non-PPI users, even after accounting for baseline differences between users and non-users. This discovery was replicated in a second study, in which over 240,000 patients were followed from 1997 to 2014. "In both studies, people who used a different class of medications to suppress stomach acid, known as H2-blockers, did not have a higher risk of developing kidney disease," said Dr. Lazarus. "If we know the potential adverse effects of PPI medications we can design better interventions to reduce overuse."

In another study, Pradeep Arora, MD (SUNY, Buffalo) and his team found that among 24,149 patients who developed CKD between 2001 and 2008 (out of a total of 71,516 patients), 25.7% were treated with PPIs. Among the total group of patients, those who took PPIs were less likely to have vascular disease, cancer, diabetes, hypertension, and chronic obstructive pulmonary disease, but PPI use was linked with a 10% increased risk of CKD and a 76% increased risk of dying prematurely.

"As a large number of patients are being treated with PPIs, health care providers need to be better educated about the potential side effects of these drugs, such as CKD," said Dr. Arora. "PPIs are often prescribed outside of their approved uses, and it has been estimated that up to two-thirds of all people on PPIs do not have a verified indication for the drug."

Studies:

1) "Proton Pump Inhibitor Use is Associated with Incident Chronic Kidney Disease" (Abstract SA-OR005)

2) "Proton Pump Inhibitors Are Associated with Increased Risk of Development of Chronic Kidney Disease" (Abstract TH-PO574).

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Materials provided by American Society of Nephrology (ASN). Note: Content may be edited for style and length.