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Age doesn't affect survival outcomes in patients with MDS who receive a HCT

Date:
December 6, 2015
Source:
Center for International Blood and Marrow Transplant Research
Summary:
A prospective study shows age doesn't affect survival outcomes in patients with myelodysplastic syndrome (MDS) who receive a hematopoietic cell transplant.
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Results from a prospective study of 1,280 patients with myelodysplastic syndrome (MDS) showed that survival at 100 days and at two years following hematopoietic cell transplant (HCT) for patients aged 65 and older is comparable to patients aged 55 to 64. The study demonstrates that age alone should not be a determinant when considering HCT for patients with MDS. The study results were presented in an oral session at the 57th Annual Meeting of the American Society of Hematology on Sunday, Dec. 6.

The study was undertaken to demonstrate efficacy for HCT in older patients with MDS with the goal of securing coverage for HCT for Medicare beneficiaries. Previously, Medicare did not have a clear coverage policy for beneficiaries, which created an access barrier for those patients. This multi-center study--conducted by CIBMTR® (Center for International Blood and Marrow Transplant Research®)--was approved after the Centers for Medicare and Medicaid Services (CMS) established coverage for HCT for MDS through Coverage with Evidence Development (CED) in 2010. The study compared the outcomes of 688 patients aged 65 and older and 592 patients aged 55-64 who underwent allogeneic HCT for MDS from 2010 to 2014.

No significant differences were found in the two-year overall survival (42 percent compared to 46 percent, p=0.1) and 100-day mortality (p=0.16) after allogeneic HCT for patients in the 65 and older age group (median age 68) compared to patients in the 55-64 age group (median age 61) respectively. While age was not found to be prognostic of HCT outcomes, multivariate analysis showed that marrow blasts prior to transplantation, cytogenetics and Sorror co-morbidity scores were independently associated with outcomes.

"This study confirms that age alone should not be a determining factor in the decision to refer older patients for transplant consultation to determine patient eligibility for transplant," said Ehab Atallah, M.D., lead study author and associate professor of medicine at the Medical College of Wisconsin's Division of Hematology/Oncology. "Based on our observations, transplant should be considered as a treatment option with payment coverage for older patients who are eligible for HCT."

"Results of the study represent an important development for older patients and their physicians seeking access to transplant as a potential cure for MDS," said Michael Boo, J.D., study author and chief strategy officer at the National Marrow Donor Program® (NMDP)/Be The Match®. "The study acknowledges HCT as an important and effective treatment for MDS patients regardless of age."

Results of this study will be shared with CMS to determine future coverage for Medicare-eligible HCT recipients.


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Cite This Page:

Center for International Blood and Marrow Transplant Research. "Age doesn't affect survival outcomes in patients with MDS who receive a HCT." ScienceDaily. ScienceDaily, 6 December 2015. <www.sciencedaily.com/releases/2015/12/151206164811.htm>.
Center for International Blood and Marrow Transplant Research. (2015, December 6). Age doesn't affect survival outcomes in patients with MDS who receive a HCT. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/12/151206164811.htm
Center for International Blood and Marrow Transplant Research. "Age doesn't affect survival outcomes in patients with MDS who receive a HCT." ScienceDaily. www.sciencedaily.com/releases/2015/12/151206164811.htm (accessed May 23, 2017).

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