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Overlap between genetic factors associated with risk of schizophrenia, maternal age at first birth

Date:
March 23, 2016
Source:
The JAMA Network Journals
Summary:
The risk of schizophrenia in children associated with younger and older maternal age appears to be partly explained by the genetic association between schizophrenia and age at first birth, according to an article.
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The risk of schizophrenia in children associated with younger and older maternal age appears to be partly explained by the genetic association between schizophrenia and age at first birth, according to an article published online by JAMA Psychiatry.

S. Hong Lee, Ph.D., of the University of New England, New South Wales, Australia, and coauthors investigated the genetic relationship between schizophrenia and age at first birth in women using multiple independent genome-wide association study data sets.

"In summary, this study provides evidence for a significant overlap between genetic factors associated with risk of SCZ [schizophrenia] and genetic factors associated with AFB [age at first birth]. To our knowledge, this is the first study to explore a genetic relationship between SCZ and AFB using independent unrelated samples based on genomic data. We conclude that women with high genetic predisposition to SCZ tend to have their first child at an early age or a later age compared with women in the general population," the study concludes.


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Divya Mehta, Felix C. Tropf, Jacob Gratten, Andrew Bakshi, Zhihong Zhu, Silviu-Alin Bacanu, Gibran Hemani, Patrik K. E. Magnusson, Nicola Barban, Tõnu Esko, Andres Metspalu, Harold Snieder, Bryan J. Mowry, Kenneth S. Kendler, Jian Yang, Peter M. Visscher, John J. McGrath, Melinda C. Mills, Naomi R. Wray, S. Hong Lee, Ole A. Andreassen, Elvira Bramon, Richard Bruggeman, Joseph D. Buxbaum, Murray J. Cairns, Rita M. Cantor, C. Robert Cloninger, David Cohen, Benedicto Crespo-Facorro, Ariel Darvasi, Lynn E. DeLisi, Timothy Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Valentina Escott-Price, Nelson B. Freimer, Lyudmila Georgieva, Lieuwe de Haan, Frans A. Henskens, Inge Joa, Antonio Julià, Andrey Khrunin, Bernard Lerer, Svetlana Limborska, Carmel M. Loughland, Milan Macek, Patrik K. E. Magnusson, Sara Marsal, Robert W. McCarley, Andrew M. McIntosh, Andrew McQuillin, Bela Melegh, Patricia T. Michie, Derek W. Morris, Kieran C. Murphy, Inez Myin-Germeys, Ann Olincy, Jim Van Os, Christos Pantelis, Danielle Posthuma, Digby Quested, Ulrich Schall, Rodney J. Scott, Larry J. Seidman, Draga Toncheva, Paul A. Tooney, John Waddington, Daniel R. Weinberger, Mark Weiser, Jing Qin Wu. Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women. JAMA Psychiatry, 2016; DOI: 10.1001/jamapsychiatry.2016.0129

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The JAMA Network Journals. "Overlap between genetic factors associated with risk of schizophrenia, maternal age at first birth." ScienceDaily. ScienceDaily, 23 March 2016. <www.sciencedaily.com/releases/2016/03/160323115452.htm>.
The JAMA Network Journals. (2016, March 23). Overlap between genetic factors associated with risk of schizophrenia, maternal age at first birth. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2016/03/160323115452.htm
The JAMA Network Journals. "Overlap between genetic factors associated with risk of schizophrenia, maternal age at first birth." ScienceDaily. www.sciencedaily.com/releases/2016/03/160323115452.htm (accessed May 27, 2017).

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