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Scavenging of inflammatory molecules improves sepsis in mice

Date:
May 19, 2016
Source:
JCI Journals
Summary:
Scientists report on a method to scavenge inflammatory molecules that mediate sepsis in mice in a new report. Sepsis is a life-threatening complication of infection in which the molecules that the body releases to fight an infection trigger widespread inflammatory responses, resulting in damage to multiple organ systems.
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Sepsis is a life-threatening complication of infection in which the molecules that the body releases to fight an infection trigger widespread inflammatory responses, resulting in damage to multiple organ systems.

In the current issue of JCI Insight, Huan Yang of the Feinstein Institute for Medical Research, Ulf Andersson of the Karolinska Institutet and colleagues, report on a method to scavenge inflammatory molecules that mediate sepsis in mice. Treatment of mice with the protein haptoglobin resulted in removal of free hemoglobin as well as the protein HMGB1, which had not been previously known to interact with haptoglobin, but is a known mediator of inflammation.

Yang and colleagues demonstrated that immune cells known as macrophages removed haptoglobin/hemoglobin complexes as well as haptoglobin/HMGB1 complexes, thereby preventing these complexes from causing tissue damage. These findings suggest that haptoglobin-based therapies could potentially be used to treat HMGB1-mediated inflammatory diseases such as sepsis.


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Journal Reference:

  1. Huan Yang, Haichao Wang, Yaakov A. Levine, Manoj K. Gunasekaran, Yongjun Wang, Meghan Addorisio, Shu Zhu, Wei Li, Jianhua Li, Dominique P.V. de Kleijn, Peder S. Olofsson, H. Shaw Warren, Mingzhu He, Yousef Al-Abed, Jesse Roth, Daniel J. Antoine, Sangeeta S. Chavan, Ulf Andersson, Kevin J. Tracey. Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes. JCI Insight, 2016; 1 (7) DOI: 10.1172/jci.insight.85375

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JCI Journals. "Scavenging of inflammatory molecules improves sepsis in mice." ScienceDaily. ScienceDaily, 19 May 2016. <www.sciencedaily.com/releases/2016/05/160519100551.htm>.
JCI Journals. (2016, May 19). Scavenging of inflammatory molecules improves sepsis in mice. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/05/160519100551.htm
JCI Journals. "Scavenging of inflammatory molecules improves sepsis in mice." ScienceDaily. www.sciencedaily.com/releases/2016/05/160519100551.htm (accessed May 23, 2017).

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