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Prodding leukemia cells with nanoprobes could provide cancer clues

Miniature mechanical testers have the potential to chart cell degradation in the body

Date:
June 2, 2016
Source:
IOP Publishing
Summary:
Giving blood cells a gentle squeeze can reveal a great deal about their health. To find out more, researchers have used a tiny force probe to compare the mechanical responses of healthy and cancerous hematopoietic cells (biological structures that help to renew blood in the body).
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Giving blood cells a gentle squeeze can reveal a great deal about their health. To find out more, researchers in France have used a tiny force probe to compare the mechanical responses of healthy and cancerous hematopoietic cells (biological structures that help to renew blood in the body).

Publishing their results in the journal Physical Biology, the scientists report that cells harvested from the bone marrow of five leukemia patients appeared much stiffer than comparable samples taken from five healthy volunteers. Also, thanks to the sensitivity of the measurement apparatus -- an atomic force microscope -- the group was able to identify areas of localized brittle failure accompanying the stiffening of the cancerous cells.

"What makes this work so exciting to us is not simply seeing a difference between the stiffness of healthy and cancerous cells, but observing that the cancerous cells also lost their dynamic ductility and behaved as more breakable objects," commented Françoise Argoul, who led the study and is a member of the French National Centre for Research (CNRS).

Future applications

The mechanical signatures obtained by squeezing or deforming cells could potentially assist physicians in determining the presence of cancers such as leukemia in patients. Significantly, the mechanical data might also provide clues as to how long the cells have been affected by the disease.

"We would like to construct a hematopoietic cancer cell chart where the loss of cell mechanical functions could be graded, depending on the leukemia and its stage of evolution," explained Argoul.

Thinking about how the technique might be applied in a hospital setting, she added that biopsy needles could, in principle, be adapted to allow local sensing of internal soft tissue structures.

Validating the approach

Before progressing to testing cells inside the body and preparing for clinical trials, the researchers must first build up sufficient information from their measurements on isolated cells under a range of conditions in the lab.

The team was able to communicate its results rapidly to the scientific community by selecting the Letters publication option offered by the IOP Publishing journal Physical Biology.


Story Source:

Materials provided by IOP Publishing. Note: Content may be edited for style and length.


Journal Reference:

  1. B Laperrousaz, L Berguiga, F E Nicolini, C Martinez-Torres, A Arneodo, V Maguer Satta, F Argoul. Revealing stiffening and brittling of chronic myelogenous leukemia hematopoietic primary cells through their temporal response to shear stress. Physical Biology, 2016; 13 (3): 03LT01 DOI: 10.1088/1478-3975/13/3/03LT01

Cite This Page:

IOP Publishing. "Prodding leukemia cells with nanoprobes could provide cancer clues: Miniature mechanical testers have the potential to chart cell degradation in the body." ScienceDaily. ScienceDaily, 2 June 2016. <www.sciencedaily.com/releases/2016/06/160602220539.htm>.
IOP Publishing. (2016, June 2). Prodding leukemia cells with nanoprobes could provide cancer clues: Miniature mechanical testers have the potential to chart cell degradation in the body. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/06/160602220539.htm
IOP Publishing. "Prodding leukemia cells with nanoprobes could provide cancer clues: Miniature mechanical testers have the potential to chart cell degradation in the body." ScienceDaily. www.sciencedaily.com/releases/2016/06/160602220539.htm (accessed May 23, 2017).

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