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Opioids regulate spermatozoon formation, research shows

Date:
June 7, 2016
Source:
University of the Basque Country
Summary:
Infertility has become a major medical and social problem worldwide and many of the cases are due to male infertility. Yet the molecular mechanisms involved in spermatogenesis are only now beginning to emerge. A piece of research has, for the first time, described the presence of opioids in the cells involved in the formation of spermatozoa.
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Infertility has become a major medical and social problem worldwide and many of the cases are due to male infertility. Yet the molecular mechanisms involved in spermatogenesis are only now beginning to emerge. A piece of research led by the UPV/EHU doctor Nerea Subirán has for the first time described the presence of opioids in the cells involved in the formation of spermatozoa. The work has been published in Plos One.

In recent years, over 3% of births per year in developed countries have corresponded to children conceived through assisted reproduction techniques, which poses a considerable economic burden apart from physical and psychological problems. According to the World Health Organisation, the cases of infertility have increased exponentially in developed countries during the last 10 years. Specifically, male infertility represents about half of the cases of infertility. Failures during the production of spermatozoa, in other words, during spermatogenesis, produce non-functional or low-quality spermatozoa and therefore infertility. Yet the molecular mechanisms involved in the regulation of this process remain unknown despite their importance in reproductive health.

This new piece of work published in Plos One and led by the UPV/EHU researcher Nerea Subirán describes for the first time the presence of opioid receptors in the cells involved in spermatozoon formation. Opioid receptors are part of the different systems of cell communication and are capable of regulating physiological processes that require a high degree of coordination and communication between the different cell and tissue types. The study describes how these receptors participate in the spermatozoa production process in mammals. Specifically, their activation regulates the formation of the machinery that undertakes to correctly segregate the genetic information during spermatogenesis.

"Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it," explained Dr Subirán.


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Materials provided by University of the Basque Country. Note: Content may be edited for style and length.


Journal Reference:

  1. Haizea Estomba, Iraia Muñoa-Hoyos, Marta Gianzo, Itziar Urizar-Arenaza, Luis Casis, Jon Irazusta, Nerea Subirán. Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis. PLOS ONE, 2016; 11 (3): e0152162 DOI: 10.1371/journal.pone.0152162

Cite This Page:

University of the Basque Country. "Opioids regulate spermatozoon formation, research shows." ScienceDaily. ScienceDaily, 7 June 2016. <www.sciencedaily.com/releases/2016/06/160607093912.htm>.
University of the Basque Country. (2016, June 7). Opioids regulate spermatozoon formation, research shows. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/06/160607093912.htm
University of the Basque Country. "Opioids regulate spermatozoon formation, research shows." ScienceDaily. www.sciencedaily.com/releases/2016/06/160607093912.htm (accessed May 23, 2017).

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