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Chemical signal can make it easier to personalize medication

Date:
June 23, 2016
Source:
Linköping Universitet
Summary:
An international research team has searched for possible non-genetic causes of common immune diseases and discovered that there is a signal called hydroxymetylcytosine (HMC) in many regions of DNA, with genetic changes associated with several immune diseases.
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An international research team has searched for possible non-genetic causes of common immune diseases and discovered that there is a signal called hydroxymetylcytosine (HMC) in many regions of DNA, with genetic changes associated with several immune diseases.

Common diseases like allergy, diabetes and other immune diseases have increased dramatically in recent decades. This indicates that the environment may have a more important role than genes in explaining this increase.

An international research team led by the Centre for personalized medicine at Linköping University has therefore searched for possible non-genetic causes of common immune diseases. They examined the chemical signals that regulate how DNA is converted into protein.

In the study, published in Cell Reports, they found that a signal called hydroxymetylcytosine (HMC) was in many regions of DNA with genetic changes associated with several immune diseases. HMC is easily measured in samples from patients.

Associate Professor Colm Nestor, who led the study also suggests that HMC may be used diagnostically to detect disease and to personalize medication. PhD Student, Antonio Lentini, also points out that from a broader perspective, HMC provides a link between how genes and environment interact to cause disease.


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Materials provided by Linköping Universitet. Note: Content may be edited for style and length.


Journal Reference:

  1. Colm E. Nestor et al. 5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4 T Cells. Cell Reports, June 2016 DOI: 10.1016/j.celrep.2016.05.091

Cite This Page:

Linköping Universitet. "Chemical signal can make it easier to personalize medication." ScienceDaily. ScienceDaily, 23 June 2016. <www.sciencedaily.com/releases/2016/06/160623123057.htm>.
Linköping Universitet. (2016, June 23). Chemical signal can make it easier to personalize medication. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/06/160623123057.htm
Linköping Universitet. "Chemical signal can make it easier to personalize medication." ScienceDaily. www.sciencedaily.com/releases/2016/06/160623123057.htm (accessed May 26, 2017).

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