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Gene found that raises risk of childhood ear infections

Date:
October 3, 2016
Source:
Children's Hospital of Philadelphia
Summary:
A gene region that raises the risk a child will have a middle ear infection, known to doctors as acute otitis media, has been discovered by researchers. The finding may offer an early clue to helping doctors develop more effective treatments to prevent one of the most common childhood illnesses.
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Researchers have discovered a gene region that raises the risk a child will have a middle ear infection, known to doctors as acute otitis media (AOM) -- and known to parents as one reason for a screaming, unhappy preschooler. The finding may offer an early clue to helping doctors develop more effective treatments to prevent one of the most common childhood illnesses.

"Parents and pediatricians are all too familiar with this painful childhood ear infection -- it's the most frequent reason children receive antibiotics," said study leader Hakon Hakonarson, MD, PhD, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia (CHOP). "Although microbes cause this condition, it's been well known that genetics also plays a role. This is the first and largest genetic study focused on risk susceptibility for acute otitis media."

Hakonarson and colleagues from CHOP collaborated with Dutch researchers led by Gijs van Ingen and colleagues from the University Medical Center, Rotterdam, in the study published online Sept. 28 in Nature Communications.

The researchers performed a genome-wide association study (GWAS) on two discovery cohorts with DNA samples from 11,000 children. They found that an association between AOM and a site on chromosome 6 containing the gene FNDC1, and then replicated the finding in an independent pediatric cohort with data from 2000 children. Co-first author Jin Li, PhD, of CHOP, was the lead analyst on the study.

In further studies, the scientists showed that the mouse gene corresponding to FNDC1 was expressed in the animal's middle ear. "Although the gene's function in humans has not been well studied, we do know that FNDC1 codes for a protein with a role in inflammation," said Hakonarson.

Hakonarson added that learning more about the biological interactions between genes and pathogens involved in AOM, researchers hope to develop more specific therapies for the childhood infection, while learning which children are most susceptible to the disease. "As with many other diseases, early medical intervention may offer the greatest benefits," he said.


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Materials provided by Children's Hospital of Philadelphia. Note: Content may be edited for style and length.


Journal Reference:

  1. Gijs van Ingen, Jin Li, André Goedegebure, Rahul Pandey, Yun Rose Li, Michael E. March, Vincent W. V. Jaddoe, Marina Bakay, Frank D. Mentch, Kelly Thomas, Zhi Wei, Xiao Chang, Heather S. Hain, André G. Uitterlinden, Henriette A. Moll, Cornelia M. van Duijn, Fernando Rivadeneira, Hein Raat, Robert J. Baatenburg de Jong, Patrick M. Sleiman, Marc P. van der Schroeff, Hakon Hakonarson. Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene. Nature Communications, 2016; 7: 12792 DOI: 10.1038/ncomms12792

Cite This Page:

Children's Hospital of Philadelphia. "Gene found that raises risk of childhood ear infections." ScienceDaily. ScienceDaily, 3 October 2016. <www.sciencedaily.com/releases/2016/10/161003182508.htm>.
Children's Hospital of Philadelphia. (2016, October 3). Gene found that raises risk of childhood ear infections. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/10/161003182508.htm
Children's Hospital of Philadelphia. "Gene found that raises risk of childhood ear infections." ScienceDaily. www.sciencedaily.com/releases/2016/10/161003182508.htm (accessed May 23, 2017).

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