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Estimating survival in patients with lung cancer, brain metastases

Date:
November 17, 2016
Source:
The JAMA Network Journals
Summary:
A new article updates a tool to estimate survival in patients with lung cancer and brain metastases. Lung cancer is a leading cause of death in the United States and around the world. A frequent and serious consequence of the disease is metastasis to the brain.
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A new article published online by JAMA Oncology updates a tool to estimate survival in patients with lung cancer and brain metastases.

Lung cancer is a leading cause of death in the United States and around the world. A frequent and serious consequence of the disease is metastasis to the brain. New therapies mean survival from lung cancer continues to improve and patients are at increased risk of developing later complications of the disease, such as brain metastases. Understanding prognosis for lung cancer is important, both for designing individualized care and future clinical trials.

In their article, Paul W. Sperduto, M.D., M.P.P., of Minneapolis Radiation Oncology and the University of Minnesota, Minneapolis, and coauthors update the original Diagnosis-Specific Graded Prognostic Assessment(DS-GPA) with new genetic and molecular data to create a new index called the Lung-moIGPA, which can be accessed electronically.

The updated Lung-moIGPA was designed by analyzing data from 2,186 patients in a multi-institution database from 2006 through 2014 with non-small cell lung cancer and newly diagnosed brain metastases. Two new prognostic factors were used in the new Lung-moIGPA: EGFR and ALK gene mutations. The authors reported overall median survival in the patient group was 12 months.

Study limitations include its design, which cannot establish causality.

"The updated Lung-moIGPA incorporating gene alteration data into the DS-GPA is a user-friendly tool that may facilitate clinical decision-making and appropriate stratification of future clinical trials," the study concludes.


Story Source:

Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Minesh P. Mehta, MD et al. Estimating Survival in Patients With Lung Cancer and Brain MetastasesAn Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncology, November 2016 DOI: 10.1001/jamaoncol.2016.3834

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The JAMA Network Journals. "Estimating survival in patients with lung cancer, brain metastases." ScienceDaily. ScienceDaily, 17 November 2016. <www.sciencedaily.com/releases/2016/11/161117151326.htm>.
The JAMA Network Journals. (2016, November 17). Estimating survival in patients with lung cancer, brain metastases. ScienceDaily. Retrieved May 29, 2017 from www.sciencedaily.com/releases/2016/11/161117151326.htm
The JAMA Network Journals. "Estimating survival in patients with lung cancer, brain metastases." ScienceDaily. www.sciencedaily.com/releases/2016/11/161117151326.htm (accessed May 29, 2017).

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