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Circulating fatty acids ratio may help predict bariatric weight loss surgery outcome

New research suggests that the ratio of serum stearic acid to palmitic acid could be a reliable marker in predicting diabetes remission outcomes after bariatric surgery and assessing the metabolic status

Date:
January 10, 2017
Source:
Federation of American Societies for Experimental Biology
Summary:
New findings may one day help clinicians predict the outcome of roux-en-Y gastric bypass surgery.
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New findings published online in The FASEB Journal, may one day help clinicians predict the outcome of roux-en-Y gastric bypass surgerysurgery. In a study involving a small number of patients, researchers found that the serum stearic acid/palmitic acid (S/P) ratio was a reliable marker in predicting diabetes remission and assessing metabolic status. Ultimately, this study could help healthcare providers determine who might benefit the most from bariatric weight-loss surgery.

"Roux-en-Y gastric bypass surgery (RYGB), one of the most commonly used bariatric surgical procedures, showed the different efficacy in obese patients with diabetes," said Wei Jia, Ph.D., a researcher involved in the work and associate director of the Cancer Epidemiology Program at the University of Hawaii Cancer Center and also director of the Center for Translational Medicine at Shanghai Jiao Tong University Affiliated Sixth People's Hospital in Shanghai, China. "Our findings could help identify patients preoperatively who would respond most favorably to the surgery."

Jia and colleagues used two independent cohorts. The first was a longitudinal cohort of 38 obese patients with diabetes who achieved weight loss and diabetes remission after RYGB. About 32 percent of these patients showed recurrence of diabetes at the second year follow-up examination. Those patients who had higher levels of S/P before surgery had greater possibilities for diabetes remission after surgery. In the second cohort of 381 community-based human participants, overweight or obese patients with diabetes exhibited lower S/P than did body mass index-matched nondiabetic patients, which highlight the specific product-to-precursor ratios as novel markers in preoperative assessment of bariatric surgery. Adding the S/P ratio to the previously reported clinical panel of diabetes duration, HbA1c level, and fasting C-peptide level contributed a significant increase in the predictive potential.

"This is a very important new picture in the bariatric surgery field," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "Both the morbidity that necessitates the procedure and the procedure itself are steep challenges, and this study has the potential to greatly benefit patients going forward."


Story Source:

Materials provided by Federation of American Societies for Experimental Biology. Note: Content may be edited for style and length.


Journal Reference:

  1. L. Zhao, Y. Ni, H. Yu, P. Zhang, A. Zhao, Y. Bao, J. Liu, T. Chen, G. Xie, J. Panee, W. Chen, C. Rajani, R. Wei, M. Su, W. Jia, W. Jia. Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity. The FASEB Journal, 2016; DOI: 10.1096/fj.201600927R

Cite This Page:

Federation of American Societies for Experimental Biology. "Circulating fatty acids ratio may help predict bariatric weight loss surgery outcome: New research suggests that the ratio of serum stearic acid to palmitic acid could be a reliable marker in predicting diabetes remission outcomes after bariatric surgery and assessing the metabolic status." ScienceDaily. ScienceDaily, 10 January 2017. <www.sciencedaily.com/releases/2017/01/170110120605.htm>.
Federation of American Societies for Experimental Biology. (2017, January 10). Circulating fatty acids ratio may help predict bariatric weight loss surgery outcome: New research suggests that the ratio of serum stearic acid to palmitic acid could be a reliable marker in predicting diabetes remission outcomes after bariatric surgery and assessing the metabolic status. ScienceDaily. Retrieved February 26, 2017 from www.sciencedaily.com/releases/2017/01/170110120605.htm
Federation of American Societies for Experimental Biology. "Circulating fatty acids ratio may help predict bariatric weight loss surgery outcome: New research suggests that the ratio of serum stearic acid to palmitic acid could be a reliable marker in predicting diabetes remission outcomes after bariatric surgery and assessing the metabolic status." ScienceDaily. www.sciencedaily.com/releases/2017/01/170110120605.htm (accessed February 26, 2017).