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Fertility can hinge on swimming conditions in the uterus

WSU researchers see sperm swim with help from enzyme in female reproductive tract

Date:
April 19, 2017
Source:
Washington State University
Summary:
A researcher has found that the uterus in female mice contains enzymes that can break down semen, making it less gel-like, more watery, and therefore easier to swim in. This interplay between semen and the female reproductive tract can impact fertility.
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For a mammal's sperm to succeed, it must complete the swim of its life to reach and fertilize an egg. That's easier if it swims through water, not goo.

It turns out that both the male and female have a role in making that happen.

A Washington State University researcher has found that the uterus in female mice contains enzymes that can break down semen, making it less gel-like, more watery, and therefore easier to swim in. Scientists have previously thought semen is broken down by enzymes from the prostate gland.

But writing this week in the journal PLOS Genetics, Wipawee Winuthayanon, an assistant professor in WSU's School of Molecular Biosciences, reports that female mice also produce the enzyme, using estrogen to induce the process. They also saw that when a female mouse lacked a gene to make this happen, semen failed to liquefy in its uterus.

"Our studies provide the first evidence of how the interplay between semen and the female reproductive tract could impact fertility," the researchers write.

The study highlights an underappreciated complication in the physical changes that semen undergoes and the relative roles of secretions in both the male and female reproductive tracts.

"This information will advance research on semen liquefaction in the female reproductive tract, an area that has never been explored," said the researchers, "and could lead to the development of diagnostic tools for unexplained infertility cases and non-invasive contraception technologies."

Winuthayanon's colleagues on the study are post-doctoral research associate Shuai Li, honors student Marleny Garcia and research assistant Rachel L. Gewiss.


Story Source:

Materials provided by Washington State University. Note: Content may be edited for style and length.


Journal Reference:

  1. Shuai Li, Marleny Garcia, Rachel L. Gewiss, Wipawee Winuthayanon. Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo. PLOS Genetics, 2017; 13 (4): e1006743 DOI: 10.1371/journal.pgen.1006743

Cite This Page:

Washington State University. "Fertility can hinge on swimming conditions in the uterus: WSU researchers see sperm swim with help from enzyme in female reproductive tract." ScienceDaily. ScienceDaily, 19 April 2017. <www.sciencedaily.com/releases/2017/04/170419091612.htm>.
Washington State University. (2017, April 19). Fertility can hinge on swimming conditions in the uterus: WSU researchers see sperm swim with help from enzyme in female reproductive tract. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2017/04/170419091612.htm
Washington State University. "Fertility can hinge on swimming conditions in the uterus: WSU researchers see sperm swim with help from enzyme in female reproductive tract." ScienceDaily. www.sciencedaily.com/releases/2017/04/170419091612.htm (accessed May 28, 2017).

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