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Meal times may be key to managing malaria, parasite study shows

Date:
March 9, 2018
Source:
University of Edinburgh
Summary:
Malaria infections might be brought under control by managing the meal times of infected people or animals, a study suggests.
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Malaria infections might be brought under control by managing the eating habits of infected people or animals, according to a new study.

Meal times are an important driver in enabling the disease to thrive, the findings suggest.

Tests in infected mice found that malaria parasites in the blood timed their daily multiplication rhythms to match when the animals were fed. When the mice's mealtime changed, the parasites altered the timing of when they invaded red blood cells.

The parasites' rhythms were linked to daily changes of blood sugar levels in the mice, the study showed.

Interfering with the biological pathways that link eating to parasite rhythms -- perhaps through diet, or drugs that manipulate the process -- could reduce both the severity and spread of malaria infection, researchers suggest.

An international team led by the University of Edinburgh studied the timing of parasite rhythms -- in multiplication and red blood cell invasion -- in groups of malaria-infected mice.

Changing the feeding times of the animals, by allowing them to eat during the day instead of at night, altered the timing of parasite multiplication from night to day, in line with the mealtime of the mice.

Scientists now plan to examine how differences in timing impact on parasites and the biological mechanisms controlling their rhythms, to better understand how to tackle infection.

The study, in collaboration with the University of Surrey, Stanford University and King Abdullah University of Science and Technology in Saudi Arabia, was published in PLoS Pathogens and supported by the Royal Society and Wellcome.

Dr Kimberley Prior, of the University of Edinburgh's School of Biological Sciences, who led the study, said: "We were surprised by how strongly malaria infection responded to changes in the eating times of the mice they were infecting. This offers a new avenue for research. If we can disrupt the link, it could reduce both the impact and the spread of malaria infection."


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Materials provided by University of Edinburgh. Note: Content may be edited for style and length.


Journal Reference:

  1. Kimberley F. Prior, Daan R. van der Veen, Aidan J. O’Donnell, Katherine Cumnock, David Schneider, Arnab Pain, Amit Subudhi, Abhinay Ramaprasad, Samuel S. C. Rund, Nicholas J. Savill, Sarah E. Reece. Timing of host feeding drives rhythms in parasite replication. PLOS Pathogens, 2018; 14 (2): e1006900 DOI: 10.1371/journal.ppat.1006900

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University of Edinburgh. "Meal times may be key to managing malaria, parasite study shows." ScienceDaily. ScienceDaily, 9 March 2018. <www.sciencedaily.com/releases/2018/03/180309095436.htm>.
University of Edinburgh. (2018, March 9). Meal times may be key to managing malaria, parasite study shows. ScienceDaily. Retrieved March 27, 2024 from www.sciencedaily.com/releases/2018/03/180309095436.htm
University of Edinburgh. "Meal times may be key to managing malaria, parasite study shows." ScienceDaily. www.sciencedaily.com/releases/2018/03/180309095436.htm (accessed March 27, 2024).

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