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Inexpensive detector is like 'Velcro®' for cancer cells

Date:
June 6, 2018
Source:
American Chemical Society
Summary:
Researchers have developed a new type of sensor that acts like Velcro® for prostate cancer cells, sticking them to a modified frosted glass slide, like those used in science classes, so that they can be identified from blood samples. The low-cost method could help doctors better diagnose and monitor the disease.
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Researchers have developed a new type of sensor that acts like Velcro® for prostate cancer cells, sticking them to a modified frosted glass slide, like those used in science classes, so that they can be identified from blood samples. The low-cost method, reported in ACS Applied Materials & Interfaces, could help doctors better diagnose and monitor the disease.

In men with prostate cancer, some tumor cells exit the prostate gland and circulate in the blood. Detecting these cells could enable diagnosis at an earlier stage or help doctors assess whether treatment is effective. However, because circulating tumor cells are present in very small numbers, finding them can be a challenge. Previous sensors have been expensive and difficult to make. So Shudong Zhang and Shutao Wang wanted do develop a simpler, more cost-effective way to monitor prostate cancer cells in the blood.

The researchers based their device on frosted glass microscope slides, commonplace in high school science classes. The frosted area, which is used to hold and label the slide, is a sandblasted surface with tiny depressions. The researchers added a solution to the frosted slides that caused silica nanowires to grow on their surfaces, then they dangled antibodies that recognized prostate cancer cells from the nanowires. After getting captured by the antibodies, circulating tumor cells became trapped in the depressions on the slide and tangled up within the nanowires, similar to the interlocking surfaces of Velcro®. The team could then visualize the cancer cells with microscopy, and found that the device had a capture efficiency on par with other approaches, they say. When the researchers tested blood samples from prostate cancer patients, the devices detected as few as 10 tumor cells in 1 milliliter of blood.


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Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Haijun Cui, Binshuai Wang, Wenshuo Wang, Yuwei Hao, Chuanyong Liu, Kai Song, Shudong Zhang, Shutao Wang. Frosted Slides Decorated with Silica Nanowires for Detecting Circulating Tumor Cells from Prostate Cancer Patients. ACS Applied Materials & Interfaces, 2018; DOI: 10.1021/acsami.8b06072

Cite This Page:

American Chemical Society. "Inexpensive detector is like 'Velcro®' for cancer cells." ScienceDaily. ScienceDaily, 6 June 2018. <www.sciencedaily.com/releases/2018/06/180606120425.htm>.
American Chemical Society. (2018, June 6). Inexpensive detector is like 'Velcro®' for cancer cells. ScienceDaily. Retrieved April 23, 2024 from www.sciencedaily.com/releases/2018/06/180606120425.htm
American Chemical Society. "Inexpensive detector is like 'Velcro®' for cancer cells." ScienceDaily. www.sciencedaily.com/releases/2018/06/180606120425.htm (accessed April 23, 2024).

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