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Scientists develop universal Ebola treatment effective in single dose

Date:
January 9, 2019
Source:
University of Texas Medical Branch at Galveston
Summary:
There is a new medication that in one dose successfully protected nonhuman primates against a lethal infection of all strains of the deadly Ebola virus.
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There is a new medication that in one dose successfully protected nonhuman primates against a lethal infection of all strains of the deadly Ebola virus. The findings are now available in Cell Host & Microbe.

Dr. Thomas Geisbert, an Ebola researcher at The University of Texas Medical Branch, said that previous therapeutics typically were of the "one bug, one drug" variety. But because of the unpredictable nature and variety of the Ebola virus, scientists have been seeking a way to protect against different strains of the virus.

"Our experimental drug can protect against all forms of Ebola known to harm people, suggesting that it will continue to protect people if the Ebola viruses evolve over time," said Geisbert, who is a professor of microbiology and immunology at UTMB.

The team of scientists demonstrated that a two-antibody cocktail called MBP134 could fully protect nonhuman primates and ferrets against lethal Ebola virus infections of caused by the Bundibugyo and Sudan strain as well as the deadliest Zaire strain that caused the 2013-16 epidemic in West Africa and the current outbreak in the Democratic Republic of Congo.

"We were able to protect the nonhuman primates against all the Ebola species plaguing people at a single low dose," said Larry Zeitlin, president of Mapp Biopharmaceutical Inc. "Further studies exploring even lower doses could open the door to treatment via auto-injectors like the kind used for allergic reactions. The ability to quickly and efficiently provide protection against all Ebola viruses in a single dose would reduce the burden on health care workers in the field during outbreaks, especially in regions that have a less-developed infrastructure."


Story Source:

Materials provided by University of Texas Medical Branch at Galveston. Note: Content may be edited for style and length.


Journal Reference:

  1. Zachary A. Bornholdt, Andrew S. Herbert, Chad E. Mire, Shihua He, Robert W. Cross, Anna Z. Wec, Dafna M. Abelson, Joan B. Geisbert, Rebekah M. James, Md Niaz Rahim, Wenjun Zhu, Viktoriya Borisevich, Logan Banadyga, Bronwyn M. Gunn, Krystle N. Agans, Ariel S. Wirchnianski, Eileen Goodwin, Kevin Tierney, William S. Shestowsky, Ognian Bohorov, Natasha Bohorova, Jesus Velasco, Eric Ailor, Do Kim, Michael H. Pauly, Kevin J. Whaley, Galit Alter, Laura M. Walker, Kartik Chandran, Larry Zeitlin, Xiangguo Qiu, Thomas W. Geisbert, John M. Dye. A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates. Cell Host & Microbe, 2019; 25 (1): 49 DOI: 10.1016/j.chom.2018.12.005

Cite This Page:

University of Texas Medical Branch at Galveston. "Scientists develop universal Ebola treatment effective in single dose." ScienceDaily. ScienceDaily, 9 January 2019. <www.sciencedaily.com/releases/2019/01/190109155725.htm>.
University of Texas Medical Branch at Galveston. (2019, January 9). Scientists develop universal Ebola treatment effective in single dose. ScienceDaily. Retrieved June 18, 2024 from www.sciencedaily.com/releases/2019/01/190109155725.htm
University of Texas Medical Branch at Galveston. "Scientists develop universal Ebola treatment effective in single dose." ScienceDaily. www.sciencedaily.com/releases/2019/01/190109155725.htm (accessed June 18, 2024).

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