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3D-printed 'hyperelastic bone' may help generate new bone for skull reconstruction

Date:
May 16, 2019
Source:
Wolters Kluwer Health
Summary:
Defects of the skull and facial bones can pose difficult challenges for plastic and reconstructive surgeons. A synthetic material called hyperelastic bone -- readily produced by 3D-printing -- could offer a powerful new tool for use in reconstructing skull defects.
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Defects of the skull and facial bones can pose difficult challenges for plastic and reconstructive surgeons. A synthetic material called hyperelastic bone -- readily produced by 3D-printing -- could offer a powerful new tool for use in reconstructing skull defects, reports a study in the May issue of Plastic and Reconstructive Surgery®.

The experimental material accelerates bone regeneration across skull defects in rats, according to initial results by Ramille N. Shah, PhD, and colleagues of Northwestern University and University of Illinois Health, Chicago. The researchers write, "Hyperelastic bone has significant potential to be translated to craniofacial reconstructive surgery, where the need for cost-effective bone replacement grafts is enormous."

Promising New 3D-Printed Bone Replacement for Skull Reconstruction

The researchers report initial experiments with hyperelastic bone in rats with surgically created defects of the top of the skull. The surgically created defects were of a "critical size" unlikely to heal on their own -- similar to those seen in patients who have undergone surgery for brain tumors.

Hyperelastic bone is a "3D-printed synthetic scaffold," consisting mainly of bone mineral (hydroxyapatite) plus a widely used, biocompatible material (polyglycolic acid). Hyperelastic bone consists of an intricate latticework, designed to support the growth and regeneration of new bone. It[TO1] can be quickly and inexpensively produced using current 3D printing hardware platforms and is malleable enough to be press-fit or cut into shape during surgery.

In the experiments, some cranial defects were reconstructed using hyperelastic bone and others using the animal's own (autologous) bone. Autologous bone is the preferred material for reconstructing bone defects, but can be difficult to obtain -- requiring bone to be taken from a "donor site" elsewhere in the body -- and sometimes isn't available at all. In other animals, reconstruction was performed using a scaffold made of polyglycolic acid only, without bone mineral.

The 3D-printed hyperelastic bone provided good bone regeneration. On follow-up CT scans, hyperelastic bone was about 74 percent effective after eight weeks and 65 percent at 12 weeks, compared to autologous bone. In contrast, defects treated with the polyglycolic acid scaffold showed little new bone formation.

Microscopic examination showed that the hyperelastic bone scaffold was gradually surrounded first by fibrous tissue, then by new bone cells. Over time, the scaffold would be gradually replaced completely by new bone, incorporating the implanted bone mineral.

"Hyperelastic bone has significant potential to be translated to craniofacial reconstructive surgery, where the need for cost-effective bone replacement grafts is enormous," Dr. Shah and colleagues conclude. With further development, they believe this 3D-printed material may provide a valuable alternative to autologous bone and commercially available bone substitutes.

"Our study underscores the promising translational potential of this novel strategy for tissue engineering applications, particularly bone regeneration," the researchers add. They emphasize that further experimental studies will be needed to confirm the use of hyperelastic bone for specific types of craniofacial reconstruction.


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Materials provided by Wolters Kluwer Health. Note: Content may be edited for style and length.


Journal Reference:

  1. Yu-Hui Huang, Adam E. Jakus, Sumanas W. Jordan, Zari Dumanian, Kelly Parker, Linping Zhao, Pravin K. Patel, Ramille N. Shah. Three-Dimensionally Printed Hyperelastic Bone Scaffolds Accelerate Bone Regeneration in Critical-Size Calvarial Bone Defects. Plastic and Reconstructive Surgery, 2019; 143 (5): 1397 DOI: 10.1097/PRS.0000000000005530

Cite This Page:

Wolters Kluwer Health. "3D-printed 'hyperelastic bone' may help generate new bone for skull reconstruction." ScienceDaily. ScienceDaily, 16 May 2019. <www.sciencedaily.com/releases/2019/05/190516155338.htm>.
Wolters Kluwer Health. (2019, May 16). 3D-printed 'hyperelastic bone' may help generate new bone for skull reconstruction. ScienceDaily. Retrieved March 27, 2024 from www.sciencedaily.com/releases/2019/05/190516155338.htm
Wolters Kluwer Health. "3D-printed 'hyperelastic bone' may help generate new bone for skull reconstruction." ScienceDaily. www.sciencedaily.com/releases/2019/05/190516155338.htm (accessed March 27, 2024).

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