New! Sign up for our free email newsletter.
Science News
from research organizations

Negative memory storage affects depression symptoms

Inhibiting negative memories could be future depression treatment

Date:
August 12, 2019
Source:
Society for Neuroscience
Summary:
Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to new research.
Share:
FULL STORY

Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to research in mice published in JNeurosci. Inhibiting these manifestations could be a future treatment route.

Groups of neurons that are activated after an experience are thought to be the physical representation of memory. These so-called engrams in the hippocampus could be involved in depression, which is characterized by impaired recall of positive memories and increased recall of negative memories.

In a mouse model of depression, Tak Pan Wong and colleagues at Douglas Hospital Research Centre tagged the engrams that formed after mice experienced social stress and examined their social avoidance behavior. Even though all mice experienced the same stressor, only some displayed depression behaviors, indicating a predisposition to developing depression.

The depression-prone mice displayed higher concentrations of engram cells compared to the less susceptible mice, and the density of the cells correlated with the level of social avoidance behavior. Activating the engram cells increased social avoidance behavior while suppressing the cells decreased it, suggesting a role in the cognitive symptoms of depression.

Manuscript title*: Negative Memory Engrams in the Hippocampus Enhance the Susceptibility to Chronic Social Defeat Stress


Story Source:

Materials provided by Society for Neuroscience. Note: Content may be edited for style and length.


Journal Reference:

  1. Tian Rui Zhang, Amanda Larosa, Marie-Eve Di Raddo, Vanessa Wong, Alice S. Wong, Tak Pan Wong. Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress. The Journal of Neuroscience, 2019; 1958-18 DOI: 10.1523/JNEUROSCI.1958-18.2019

Cite This Page:

Society for Neuroscience. "Negative memory storage affects depression symptoms." ScienceDaily. ScienceDaily, 12 August 2019. <www.sciencedaily.com/releases/2019/08/190812130856.htm>.
Society for Neuroscience. (2019, August 12). Negative memory storage affects depression symptoms. ScienceDaily. Retrieved July 20, 2024 from www.sciencedaily.com/releases/2019/08/190812130856.htm
Society for Neuroscience. "Negative memory storage affects depression symptoms." ScienceDaily. www.sciencedaily.com/releases/2019/08/190812130856.htm (accessed July 20, 2024).

Explore More

from ScienceDaily

RELATED STORIES