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Higher levels of NETs in blood associated with more severe COVID-19

Date:
April 24, 2020
Source:
Michigan Medicine - University of Michigan
Summary:
A new study explores the connection between levels of a type of destructive white blood cell, known as a neutrophil, with the severity of COVID-19.
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FULL STORY

New research finds a connection between destructive white blood cells and a more severe disease course in patients with COVID-19.

"We found that patients with COVID-19 infection have higher blood levels of neutrophil extracellular traps, also called NETs, which are a product of an inflammatory type of neutrophil cell death called NETosis," says first author Yu (Ray) Zuo, M.D., a Michigan Medicine rheumatologist.

Zuo worked on the study with Yogen Kanthi, M.D., a cardiologist and vascular medicine specialist at the Michigan Medicine Frankel Cardiovascular Center, and Jason Knight, M.D., Ph.D., a rheumatologist at Michigan Medicine, who study inflammation and neutrophils. The researchers analyzed blood samples from 50 patients with COVID-19 for this publication.

Zuo and colleagues say, in light of the COVID-19 pandemic, there is an urgent need to better understand what causes the inflammatory storm and blood clots triggered by SARS-CoV-2 infection -- a storm that leads to respiratory failure and a requirement for mechanical ventilation in many patients. They believe NETs may be relevant to many aspects of COVID-19 research, given that thrombosis and inflammation are hallmarks of severe infection.

This is the first publication to come out of the Frankel CVC's CV Impact Research Ignitor Grant program, which was created to address COVID-19 from both basic science and clinical perspectives.


Story Source:

Materials provided by Michigan Medicine - University of Michigan. Original written by Haley Otman. Note: Content may be edited for style and length.


Journal Reference:

  1. Yu Zuo, Srilakshmi Yalavarthi, Hui Shi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Christopher N. Blair, Andrew Weber, Betsy J. Barnes, Mikala Egeblad, Robert J. Woods, Yogendra Kanthi, Jason S. Knight. Neutrophil extracellular traps in COVID-19. JCI Insight, 2020; DOI: 10.1172/jci.insight.138999

Cite This Page:

Michigan Medicine - University of Michigan. "Higher levels of NETs in blood associated with more severe COVID-19." ScienceDaily. ScienceDaily, 24 April 2020. <www.sciencedaily.com/releases/2020/04/200424174044.htm>.
Michigan Medicine - University of Michigan. (2020, April 24). Higher levels of NETs in blood associated with more severe COVID-19. ScienceDaily. Retrieved May 23, 2024 from www.sciencedaily.com/releases/2020/04/200424174044.htm
Michigan Medicine - University of Michigan. "Higher levels of NETs in blood associated with more severe COVID-19." ScienceDaily. www.sciencedaily.com/releases/2020/04/200424174044.htm (accessed May 23, 2024).

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