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New model may explain rarity of certain malaria-blocking mutations

If people rapidly become immune against severe effects, some protective mutations fail to spread

Date:
October 8, 2020
Source:
PLOS
Summary:
A new computational model suggests that certain mutations that block infection by the most dangerous species of malaria have not become widespread in people because of the parasite's effects on the immune system.
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A new computational model suggests that certain mutations that block infection by the most dangerous species of malaria have not become widespread in people because of the parasite's effects on the immune system. Bridget Penman of the University of Warwick, U.K., and Sylvain Gandon of the CNRS and Montpellier University, France, present these findings in the open-access journal PLOS Computational Biology.

Malaria is a potentially lethal, mosquito-borne disease caused by parasites of the Plasmodium genus. Several protective adaptations to malaria have spread widely among humans, such as the sickle-cell mutation. Laboratory experiments suggest that certain other mutations could be highly protective against the most dangerous human-infecting malaria species, Plasmodium falciparum. However, despite being otherwise benign, these mutations have not become widespread.

To help clarify why some protective mutations may remain rare, Penman and colleagues developed a computational model that simulates the epidemiology of malaria infection, as well the evolution of protective mutations. Importantly, the model also incorporates mechanisms of adaptive immunity, in which the immune system "learns" to recognize and attack specific pathogens, such as P. falciparum.

Analysis of the model's predictions suggests that if people rapidly gain adaptive immunity to the severe effects of P. falciparum malaria, mutations capable of blocking P. falciparum infection are unlikely to spread among the population. The fewer the number of infections it takes for people to become immune to the severe effects of malaria, the less likely it is that malaria infection-blocking mutations will arise.

"Understanding why a potential human malaria adaptation has not succeeded could be just as important as understanding those which have succeeded," Penman says. "Our results highlight the need for further detailed genetic studies of populations living in regions impacted by malaria in order to better understand malaria-human interactions."

Ultimately, understanding how humans have adapted to malaria could help open up new avenues for treatment.


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Materials provided by PLOS. Note: Content may be edited for style and length.


Journal Reference:

  1. Bridget S. Penman, Sylvain Gandon. Adaptive immunity selects against malaria infection blocking mutations. PLOS Computational Biology, 2020; 16 (10): e1008181 DOI: 10.1371/journal.pcbi.1008181

Cite This Page:

PLOS. "New model may explain rarity of certain malaria-blocking mutations." ScienceDaily. ScienceDaily, 8 October 2020. <www.sciencedaily.com/releases/2020/10/201008142110.htm>.
PLOS. (2020, October 8). New model may explain rarity of certain malaria-blocking mutations. ScienceDaily. Retrieved April 18, 2024 from www.sciencedaily.com/releases/2020/10/201008142110.htm
PLOS. "New model may explain rarity of certain malaria-blocking mutations." ScienceDaily. www.sciencedaily.com/releases/2020/10/201008142110.htm (accessed April 18, 2024).

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