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Skin and immune cells coordinate defenses against assault

Date:
May 6, 2021
Source:
Yale University
Summary:
As the human body's largest organ, the skin is responsible for protecting against a wide range of possible infections on all fleshy surfaces, from head to toe. So how exactly does the skin organize its defenses against such an array of threats?
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As the human body's largest organ, the skin is responsible for protecting against a wide range of possible infections on all fleshy surfaces, from head to toe. So how exactly does the skin organize its defenses against such an array of threats?

A new Yale study shows that the epidermis, the outermost layer of skin, is composed of an army of immune cells that station themselves at regular intervals across the skin's vast expanse to resist infection. When necessary, the researchers found, these immune system soldiers are able to reposition themselves to protect vulnerable areas.

The study, published in the journal Nature Cell Biology, was conducted by the lab of Valentina Greco, the Carolyn Walch Slayman Professor of Genetics, at Yale School of Medicine.

"It's a surveillance system with two separate roles," said Catherine Matte-Martone, manager of the Greco lab and co-first author of the study. "The skin controls the sentinels by mediating their numbers based on its own density, while they in turn provide dynamic coverage to prevent cracks in the skin's defenses."

The epidermis contains two main types of immune system cells, Langerhans cells (LCs) and dendritic epidermal T cells (DETCs). In the study, the research team led by Matte-Martone and Sangbum Park, a researcher from Michigan State University (MSU), captured images of these immune system cells interacting with epithelial cells, the closely packed skin cells that comprise most of the epidermis.

They found that the immune system cells are distributed in a distinct pattern, maintaining a minimum distance between the individual cells. According to the researchers, these immune cells seem to have the ability to avoid each other, preventing clusters in any locations and maintaining a consistent distribution.

The phenomenon is similar to a property observed in neurons, in which scientists have observed a tendency of neurons from a single branch to avoid each other.

"Our study suggests that LCs and DETCs appear to have a mechanism of 'self-avoidance,' similar to neuronal cells," said Park, an assistant professor at MSU and former postdoctoral fellow in the Greco lab at Yale.

When the team removed some immune cells in one area, they observed that the remaining cells were able to reposition across the skin tissue to defend the gaps in coverage. They also found that they could disrupt the normal distribution of those cells by knocking out a gene known as Rac1 (Ras-related C3 botulinum toxin substrate 1), which regulates projections on immune cells called dendrites. This process, they hypothesize, helps maintain the distance between immune cells.

The findings illustrate how specialized cell types can cooperate to carry out a larger role within the body.

"It is fascinating to observe how these different cell types co-exist and interact together in a developmental context rather than an immunological one," Martone said.

Other Yale authors include Ann Haberman, director of the In Vivo Imaging Facility at Yale, and David Gonzalez, manager of both the Imaging Facility and the Greco Lab.

The research was funded by the National Institutes of Health.


Story Source:

Materials provided by Yale University. Original written by Bill Hathaway. Note: Content may be edited for style and length.


Journal Reference:

  1. Sangbum Park, Catherine Matte-Martone, David G. Gonzalez, Elizabeth A. Lathrop, Dennis P. May, Cristiana M. Pineda, Jessica L. Moore, Jonathan D. Boucher, Edward Marsh, Axel Schmitter-Sánchez, Katie Cockburn, Olga Markova, Yohanns Bellaïche, Valentina Greco. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Nature Cell Biology, 2021; 23 (5): 476 DOI: 10.1038/s41556-021-00670-5

Cite This Page:

Yale University. "Skin and immune cells coordinate defenses against assault." ScienceDaily. ScienceDaily, 6 May 2021. <www.sciencedaily.com/releases/2021/05/210506163609.htm>.
Yale University. (2021, May 6). Skin and immune cells coordinate defenses against assault. ScienceDaily. Retrieved May 27, 2024 from www.sciencedaily.com/releases/2021/05/210506163609.htm
Yale University. "Skin and immune cells coordinate defenses against assault." ScienceDaily. www.sciencedaily.com/releases/2021/05/210506163609.htm (accessed May 27, 2024).

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