New! Sign up for our free email newsletter.
Science News
from research organizations

What level of antibody response protects against COVID-19 death?

Date:
October 6, 2021
Source:
Wiley
Summary:
In a new study of patients with COVID-19 being treated in intensive care units, people who mounted only a low antibody response against the SARS-CoV-2 virus faced a higher risk of dying.
Share:
FULL STORY

In a study of patients with COVID-19 being treated in intensive care units, people who mounted only a low antibody response against the SARS-CoV-2 virus faced a higher risk of dying.

The study, which is published in the Journal of Internal Medicine, also found that patients with strong antibody responses against the virus had low levels of viral RNA in their blood. On the contrary, those with poor antibody responses had high viral RNA levels and disseminated viral proteins in the blood.

The results could help establish the optimal antibody levels needed for an individual to overcome COVID-19 when critically ill. The study also provided evidence of the importance of antibodies against the spike protein of SARS-CoV-2 to block the virus' replication. These are the antibodies that are induced by vaccination.

"Our findings support that treatment with exogenous antibodies in COVID-19 should be personalized, reserving this therapy for those patients with absent or low endogenous antibodies levels," said co-senior author Jesús F. Bermejo-Martin, MD, PhD, of the Instituto de Investigación Biomédica de Salamanca (IBSAL) & CIBERES, in Spain.


Story Source:

Materials provided by Wiley. Note: Content may be edited for style and length.


Journal Reference:

  1. María Martin‐Vicente, Raquel Almansa, Isidoro Martínez, Ana P. Tedim, Elena Bustamante, Luis Tamayo, César Aldecoa, José Manuel Gómez, Gloria Renedo, Jose Ángel Berezo, Jamil Antonio Cedeño, Nuria Mamolar, Pablo García Olivares, Rubén Herrán‐Monge, Ramón Cicuendez, Pedro Enríquez, Alicia Ortega, Noelia Jorge, Cristina Doncel, Amanda de la Fuente, Juan Bustamante‐Munguira, María José Muñoz‐Gómez, Milagros González‐Rivera, Carolina Puertas, Vicente Más, Mónica Vázquez, Felipe Pérez‐García, Jesús Rico‐Feijoo, Silvia Martín, Anna Motos, Laia Fernandez‐Barat, Jose María Eiros, Marta Dominguez‐Gil, Ricard Ferrer, Ferrán Barbé, Wysali Trapiello, David J. Kelvin, Jesús F. Bermejo‐Martin, Salvador Resino, Antoni Torres. Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients. Journal of Internal Medicine, 2021; DOI: 10.1111/joim.13386

Cite This Page:

Wiley. "What level of antibody response protects against COVID-19 death?." ScienceDaily. ScienceDaily, 6 October 2021. <www.sciencedaily.com/releases/2021/10/211006080547.htm>.
Wiley. (2021, October 6). What level of antibody response protects against COVID-19 death?. ScienceDaily. Retrieved June 16, 2024 from www.sciencedaily.com/releases/2021/10/211006080547.htm
Wiley. "What level of antibody response protects against COVID-19 death?." ScienceDaily. www.sciencedaily.com/releases/2021/10/211006080547.htm (accessed June 16, 2024).

Explore More

from ScienceDaily

RELATED STORIES