New! Sign up for our free email newsletter.
Science News
from research organizations

Researchers use foundation models to discover new cancer imaging biomarkers

Date:
May 7, 2024
Source:
Mass General Brigham
Summary:
Researchers have harnessed the technology behind foundation models, which power tools like ChatGPT, to discover new cancer imaging biomarkers that could transform how patterns are identified from radiological images. Improved identification of such patterns can greatly impact the early detection and treatment of cancer.
Share:
FULL STORY

Researchers at Mass General Brigham have harnessed the technology behind foundation models, which power tools like ChatGPT, to discover new cancer imaging biomarkers that could transform how patterns are identified from radiological images. Improved identification of such patterns can greatly impact the early detection and treatment of cancer.

The research team developed their foundation model using a comprehensive dataset consisting of 11,467 images of abnormal radiologic scans. Using these images, the model was able to identify patterns that predict anatomical site, malignancy, and prognosis across three different use cases in four cohorts. Compared to existing methods in the field, their approach remained powerful when applied to specialized tasks where only limited data are available. Results are published in Nature Machine Intelligence.

"Given that image biomarker studies are tailored to answer increasingly specific research questions, we believe that our work will enable more accurate and efficient investigations," said first author Suraj Pai from the Artificial Intelligence in Medicine (AIM) Program at Mass General Brigham.

Despite the improved efficacy of AI methods, a key question remains their reliability and explainability (the concept that an AI's answers can be explained in a way that "makes sense" to humans). The researchers demonstrated that their methods remained stable across inter-reader variations and differences in acquisition. Patterns identified by the foundation model also demonstrated strong associations with underlying biology, mainly correlating with immune-related pathways.

"Our findings demonstrate the efficacy of foundation models in medicine when only limited data might be available for training deep learning networks, especially when applied to identifying reliable imaging biomarkers for cancer-associated use cases," said senior author Hugo Aerts, PhD, director of the AIM Program.


Story Source:

Materials provided by Mass General Brigham. Note: Content may be edited for style and length.


Journal Reference:

  1. Suraj Pai, Dennis Bontempi, Ibrahim Hadzic, Vasco Prudente, Mateo Sokač, Tafadzwa L. Chaunzwa, Simon Bernatz, Ahmed Hosny, Raymond H. Mak, Nicolai J. Birkbak, Hugo J. W. L. Aerts. Foundation model for cancer imaging biomarkers. Nature Machine Intelligence, 2024; 6 (3): 354 DOI: 10.1038/s42256-024-00807-9

Cite This Page:

Mass General Brigham. "Researchers use foundation models to discover new cancer imaging biomarkers." ScienceDaily. ScienceDaily, 7 May 2024. <www.sciencedaily.com/releases/2024/05/240507145252.htm>.
Mass General Brigham. (2024, May 7). Researchers use foundation models to discover new cancer imaging biomarkers. ScienceDaily. Retrieved May 23, 2024 from www.sciencedaily.com/releases/2024/05/240507145252.htm
Mass General Brigham. "Researchers use foundation models to discover new cancer imaging biomarkers." ScienceDaily. www.sciencedaily.com/releases/2024/05/240507145252.htm (accessed May 23, 2024).

Explore More

from ScienceDaily

RELATED STORIES