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Mobile phone data helps track pathogen spread and evolution of superbugs

Date:
July 3, 2024
Source:
Wellcome Trust Sanger Institute
Summary:
Combining genomic data and human travel patterns over a 14-year period in South Africa reveals key insights into the spread, evolution and resistance patterns of a major bacterium behind pneumonia and meningitis globally.
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FULL STORY

A new way to map the spread and evolution of pathogens, and their responses to vaccines and antibiotics, will provide key insights to help predict and prevent future outbreaks. The approach combines a pathogen's genomic data with human travel patterns, taken from anonymised mobile phone data.

Researchers from the Wellcome Sanger Institute, University of the Witwatersrand and National Institute for Communicable Diseases in South Africa, the University of Cambridge, and partners across the Global Pneumococcal Sequencing project1, integrated genomic data from nearly 7,000 Streptococcus pneumoniae (pneumococcus)samples collected in South Africa with detailed human mobility data2. This enabled them to see how these bacteria, which cause pneumonia and meningitis3, move between regions and evolve over time.

The findings, published today (3 July) in Nature, suggest initial reductions in antibiotic resistance linked to the 2009 pneumococcal vaccine may be only temporary, as non-targeted strains resistant to antibiotics such as penicillin gained a 68 per cent competitive advantage.

This is the first time researchers have been able to precisely quantify the fitness -- their ability to survive and reproduce -- of different pneumococcal strains. The insight could inform vaccine development to target the most harmful strains, and may be applicable to other pathogens.

Many infectious diseases such as tuberculosis, HIV, and COVID-19 exist in multiple strains or variants circulating simultaneously, making them difficult to study. Pneumococcus, a bacterium that is a leading cause of pneumonia, meningitis, and sepsis worldwide4, is a prime example with over 100 types and 900 genetic strains globally. Pneumonia alone kills around 740,000 children under the age of five each year5, making it the single largest infectious cause of death in children.

Pneumococcal diversity hampers control efforts, as vaccines targeting major strains leave room for others to fill the vacant niches. How these bacteria spread, how vaccines affect their survival, and their resistance to antibiotics remains poorly understood.

In this new study, researchers analysed genome sequences from 6,910 pneumococcus samples collected in South Africa between 2000 and 2014 to track the distribution of different strains over time. They combined these data with anonymised records of human travel patterns collected by Meta2.

The team developed computational models which revealed pneumococcal strains take around 50 years to fully mix throughout South Africa's population, largely due to localised human movement patterns.

They found that while introduction of a pneumococcal vaccine against certain types of these bacteria in 2009 reduced the number of cases caused by those types6, it also made other non-targeted strains of these bacteria gain a 68 per cent competitive advantage, with an increasing proportion of them becoming resistant to antibiotics such as penicillin. This suggests that the vaccine-linked protection against antibiotic resistance is short-lived.

Dr Sophie Belman, first author of the study, former PhD student at the Wellcome Sanger Institute and now a Schmidt Science Fellow at the Barcelona Supercomputing Centre, Spain, said: "While we found that pneumococcal bacteria generally spread slowly, the use of vaccines and antimicrobials can quickly and significantly change these dynamics. Our models could be applied to other regions and pathogens to better understand and predict pathogen spread, in the context of drug resistance and vaccine effectiveness."

Dr Anne von Gottberg, author of the study at National Institute for Communicable Diseases, Johannesburg, South Africa, said: "Despite vaccination efforts, pneumonia remains one of the leading causes of death for children under five in South Africa. With continuous genomic surveillance and adaptable vaccination strategies to counter the remarkable adaptability of these pathogens, we may be able to better target interventions to limit the burden of disease."

Professor Stephen Bentley, senior author of the study at the Wellcome Sanger Institute, said: "The pneumococcus's diversity has obscured our view on how any given strain spreads from one region to the next. This integrated approach using bacterial genome and human travel data finally allows us to cut through that complexity, uncovering hidden migratory paths in high-definition for the first time. This could allow researchers to anticipate where emerging high-risk strains may take hold next, putting us a step ahead of potential outbreaks."

Notes

  1. Partners from the Global Pneumococcal Sequencing project can be found here: https://www.pneumogen.net/gps/
  2. The human mobility data used in this study are Meta Data for Good baseline data, released during the 2020 SARS-CoV-2 pandemic. These data rely on personal consent for location sharing, and Data for Good ensures individual privacy by preventing re-identification in aggregated datasets.
  3. For more information on pneumococcal disease, visit: https://www.cdc.gov/pneumococcal/about/index.html
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666185/
  5. https://www.who.int/news-room/fact-sheets/detail/pneumonia
  6. Before these vaccines, 85 per cent of pneumococcal strains were those targeted by the vaccines. By 2014, this dropped to 33.2 per cent. This change was consistent across all nine provinces in South Africa.

Story Source:

Materials provided by Wellcome Trust Sanger Institute. Note: Content may be edited for style and length.


Journal Reference:

  1. Sophie Belman, Noémie Lefrancq, Susan Nzenze, Sarah Downs, Mignon du Plessis, Stephanie W. Lo, Alejandra Corso, Paula Gagetti, Abdullah W. Brooks, Md Hasanuzzaman, Samir K. Saha, Senjuti Saha, Alexander Davydov, Leonid Titov, Samanta Cristine Grassi Almeida, Paul Turner, Chunjiang Zhao, Hui Wang, Margaret Ip, Pak Leung Ho, Pierra Law, Jeremy D. Keenan, Robert Cohen, Emmanuelle Varon, Eric Sampane-Donkor, Balaji Veeraraghavan, Geetha Nagaraj, K. L. Ravikumar, J. Yuvaraj, Varun Shamanna Noga, Rachel Benisty, Ron Dagan, Godfrey Bigogo, Jennifer Verani, Anmol Kiran, Dean B. Everett, Jennifer Cornick, Maaike Alaerts, Shamala Devi Sekaran, Stuart C. Clarke, Benild Moiane, Betuel Sigauque, Helio Mucavele, Andrew J. Pollard, Rama Kandasamy, Philip E. Carter, Stephen K. Obaro, Deborah Lehmann, Rebecca Ford, Theresa J. Ochoa, Anna Skoczynska, Ewa Sadowy, Waleria Hryniewicz, Weronika Puzia, Sanjay Doiphode, Ekaterina Egorova, Elena Voropaeva, Yulia Urban, Tamara Kastrin, Kedibone Ndlangisa, Linda De Gouveia, Mushal Ali, Nicole Wolter, Cebile Lekhuleni, Carmen Muñoz Almagro, Alba Redin Alonso, Desiree Henares, Somporn Srifuengfung, Brenda Kwambana-Adams, Ebenezer Foster-Nyarko, Ebrima Bojang, Martin Antonio, Peggy-Estelle Tientcheu, Jennifer Moïsi, Michele Nurse-Lucas, Patrick E. Akpaka, Özgen Köseoglu Eser, Anthony Scott, David Aanensen, Nicholas Croucher, John A. Lees, Rebecca A. Gladstone, Gerry Tonkin-Hill, Chrispin Chaguza, David Cleary, Kate Mellor, Bernard Beall, Keith P. Klugman, Gail Rodgers, Paulina A. Hawkins, Anne J. Blaschke, Nicole L. Pershing, Lesley McGee, Shabir A. Madhi, Anne von Gottberg, Stephen D. Bentley, Henrik Salje. Geographical migration and fitness dynamics of Streptococcus pneumoniae. Nature, 2024; DOI: 10.1038/s41586-024-07626-3

Cite This Page:

Wellcome Trust Sanger Institute. "Mobile phone data helps track pathogen spread and evolution of superbugs." ScienceDaily. ScienceDaily, 3 July 2024. <www.sciencedaily.com/releases/2024/07/240703131714.htm>.
Wellcome Trust Sanger Institute. (2024, July 3). Mobile phone data helps track pathogen spread and evolution of superbugs. ScienceDaily. Retrieved July 23, 2024 from www.sciencedaily.com/releases/2024/07/240703131714.htm
Wellcome Trust Sanger Institute. "Mobile phone data helps track pathogen spread and evolution of superbugs." ScienceDaily. www.sciencedaily.com/releases/2024/07/240703131714.htm (accessed July 23, 2024).

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