Featured Research

from universities, journals, and other organizations

Researchers Create A New Type Of Antibiotics Effective Against Many Bacteria

Date:
June 12, 2000
Source:
American Chemical Society
Summary:
Like weeds in a garden, disease-causing bacteria resist our efforts to stamp them out. Now researchers have a new tool to address the growing problem of antibiotic resistance.

Like weeds in a garden, disease-causing bacteria resist our efforts to stamp them out. Now researchers have a new tool to address the growing problem of antibiotic resistance. The achievement is reported in the May 31 edition of the Journal of the American Chemical Society, a peer-reviewed journal of the world's largest scientific society.

Related Articles


The researchers focused on aminoglycosides, a family of antibiotics that includes drugs such as neomycin, used in common ointments like Neosporin™. This class of antibiotics faces threats from its inherent high toxicity and its susceptibility to chemical modifications that allow bacteria to resist the drug's effects.

Bacteria, which create the proteins they need to survive, are constantly evolving and mutating in ways that circumvent the activity of antibiotics. To get around this problem, the researchers found a way to bind the antibiotic to the bacteria's protein-making machinery (called ribonucleic acid, or RNA). This prevents the formation of proteins that allow the bacteria to become resistant to antibiotics, according to Chi-Huey Wong, lead author for research team at the Scripps Research Institute in California.

The approach could yield an antibiotic approximately 1,000 times more effective than the original antibiotic, so a much smaller dose would suffice, Wong said.

"By studying the bacterial genome, we were able to find a way to attack antibiotic resistance," Wong said. "We used it as a new way to find the secrets of resistance."

More than 100 antibiotics are currently on the market to fight infections, including those suffered by cancer and AIDS patients, people recovering from surgery and others. They work by preventing the growth of bacteria that lead to infections.

Wong said the researchers worked with aminoglycosides because they function differently than other antibiotics, preventing the formation of proteins that allow bacteria to live, instead of attacking the proteins after they are formed. The same method might be used to develop anticancer and antiviral agents, he added.

Although human testing is expected to begin within six months, any solution to the problem of antibiotic resistance is temporary, Wong said.

"The best we can do is slow down the development of resistance," Wong said. "It's just a matter of time with bacteria. It's simply evolution -- bacteria will do anything to survive."


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Researchers Create A New Type Of Antibiotics Effective Against Many Bacteria." ScienceDaily. ScienceDaily, 12 June 2000. <www.sciencedaily.com/releases/2000/06/000612084831.htm>.
American Chemical Society. (2000, June 12). Researchers Create A New Type Of Antibiotics Effective Against Many Bacteria. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2000/06/000612084831.htm
American Chemical Society. "Researchers Create A New Type Of Antibiotics Effective Against Many Bacteria." ScienceDaily. www.sciencedaily.com/releases/2000/06/000612084831.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins