Featured Research

from universities, journals, and other organizations

UIC Research Points To New Class Of Drugs To Combat Antibiotic Resistance

Date:
May 29, 2001
Source:
University Of Illinois At Chicago
Summary:
Fundamental research at the UIC Center for Pharmaceutical Biotechnology to be published this week in the journal Nature (May 24) could lead to the development of a new class of antibiotics to help combat the growing global health problem of antibiotic resistance.

Fundamental research at the UIC Center for Pharmaceutical Biotechnology to be published this week in the journal Nature (May 24) could lead to the development of a new class of antibiotics to help combat the growing global health problem of antibiotic resistance.

Related Articles


Roughly two-thirds of all antibiotics kill bacteria by acting on ribosome. They penetrate bacteria and interfere with protein synthesis. Researchers only recently have begun to understand how these antibiotics work.

Alexander Mankin, associate professor of medicinal chemistry in the UIC College of Pharmacy, and his team have found that ribosome can remain functional even after alterations are made to the one nucleotide understood by researchers to be critical for catalytic activity. "The expectation was that if you made mutations at this nucleotide you would kill the ribosome and it no longer would be able to synthesize protein but, in fact, it still could," said Mankin. "We didn't believe it ourselves initially but several independent experiments confirmed our original finding."

This finding brings researchers closer to understanding how ribosome functions and contradicts the commonly held belief among scientists that ribosome functions as a chemical enzyme. It strongly suggests that chemical catalytic activity may not be essential for protein synthesis. Protein synthesis may come about spontaneously when ribosome positions substrates close together. This activity is called peptide bond formation.

Understanding how ribosome functions is likely to enable researchers to understand better how many antibiotics inhibit activity that is critical to bacterial growth.

This finding makes sense from an evolutionary perspective, Mankin says. According to the RNA world theory, life on this planet began as RNA molecules that reproduced without protein. Unlike modern cells in which proteins are catalysts of most chemical reactions, ancient ribosome probably was made of RNA, which is a poor chemical catalyst but efficient at binding substrates. Researchers do not yet understand the transition from RNA growth to modern cell growth, in which the reaction is catalyzed by protein. Though proteins have assumed many RNA functions, it still is RNA that promotes peptide bond formation.

The UIC team's finding suggests that drugs that interfere with binding of ribosomal substrates may block bacterial protein synthesis and, hence, be most effective against antibiotic-resistant bacteria.

The next step for Mankin's UIC laboratory is to determine whether ribosome can function without proteins. The UIC researchers are most interested in ribosomal RNA, in part because the main target of antibiotics that act on ribosome is not protein, but RNA.

The UIC laboratory is working to understand how ribosome works in general and how antibiotics that affect ribosome work.

For more information about the University of Illinois at Chicago, visit http://www.uic.edu


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "UIC Research Points To New Class Of Drugs To Combat Antibiotic Resistance." ScienceDaily. ScienceDaily, 29 May 2001. <www.sciencedaily.com/releases/2001/05/010529065740.htm>.
University Of Illinois At Chicago. (2001, May 29). UIC Research Points To New Class Of Drugs To Combat Antibiotic Resistance. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2001/05/010529065740.htm
University Of Illinois At Chicago. "UIC Research Points To New Class Of Drugs To Combat Antibiotic Resistance." ScienceDaily. www.sciencedaily.com/releases/2001/05/010529065740.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins