Featured Research

from universities, journals, and other organizations

Yale Researchers Develop First Vaccine For West Nile Virus Tested Successfully In Animal Model Of The Disease

Date:
November 1, 2001
Source:
Yale University
Summary:
Yale scientists have successfully immunized mice against West Nile virus, raising the possibility of developing a vaccine for humans against the potentially fatal, mosquito-borne infection.

Yale scientists have successfully immunized mice against West Nile virus, raising the possibility of developing a vaccine for humans against the potentially fatal, mosquito-borne infection.

Although there have been about 10 virus-related deaths reported to date in the United States, West Nile virus is considered an emerging disease, according to Erol Fikrig, M.D., associate professor of medicine and in the Department of Epidemiology and Public Health at Yale School of Medicine, who directed the study. "Its seriousness as a public health threat is not fully known yet," he said. "That should become apparent over the next two to three years. If the vaccine proves necessary, its development will be valuable."

Results of the study were published online in the Journal of Immunology on October 23 and appeared in the November 1 print issue.

West Nile virus was first identified in Uganda in 1937 and has since infected people in many other parts of the world. It was seen for the first time in humans in the U.S. in the New York City area in 1999. Sporadic cases have since appeared around the Northeast and in the South and Midwest. The virus, which infects birds as well as humans, spreads through mosquito bites primarily in warm weather months.

There is currently no cure for West Nile virus, although infection does not generally cause serious consequences. Elderly patients, however, can develop fatal encephalitis, a central nervous system infection.

Fikrig, Tian Wang, a post-doctoral fellow in his laboratory, and other Yale colleagues worked with John F. Anderson and associates from the Connecticut Agricultural Experiment Station in New Haven to isolate the virus found in an infected bird. They genetically engineered a protein in the virus, which they then injected into uninfected mice. Immunization with the vaccine provided complete protection for the animals against West Nile virus.

Diagnosis of West Nile virus can be difficult using current methods. The protein used to make the vaccine could also potentially be employed to develop a diagnostic test.

Other participants in the study included Louis A. Magnarelli of the Connecticut Agricultural Experiment Station, Susan J. Wong of the New York State Department of Health, and Raymond A. Koski of L2 Diagnostics, Inc.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Yale Researchers Develop First Vaccine For West Nile Virus Tested Successfully In Animal Model Of The Disease." ScienceDaily. ScienceDaily, 1 November 2001. <www.sciencedaily.com/releases/2001/11/011101060548.htm>.
Yale University. (2001, November 1). Yale Researchers Develop First Vaccine For West Nile Virus Tested Successfully In Animal Model Of The Disease. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2001/11/011101060548.htm
Yale University. "Yale Researchers Develop First Vaccine For West Nile Virus Tested Successfully In Animal Model Of The Disease." ScienceDaily. www.sciencedaily.com/releases/2001/11/011101060548.htm (accessed September 16, 2014).

Share This



More Plants & Animals News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Conservationists Face Uphill PR Battle With New Shark Rules

Conservationists Face Uphill PR Battle With New Shark Rules

Newsy (Sep. 14, 2014) New conservation measures for shark fishing face an uphill PR battle in the fight to slow shark extinction. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins