Featured Research

from universities, journals, and other organizations

Yale Researchers Discover New Potential Asthma Therapeutic Targets Related To Parasites And Insects

Date:
June 14, 2004
Source:
Yale University
Summary:
An unusual protein called acidic mammalian chitinase (AMCase), is markedly increased in mouse models of asthma, making it an important link in finding the pathways that lead to asthma, Yale researchers report in Science.

June 11, 2004 -- An unusual protein called acidic mammalian chitinase (AMCase), is markedly increased in mouse models of asthma, making it an important link in finding the pathways that lead to asthma, Yale researchers report in today's issue of Science.

Asthma is a disease produced by chronic inflammation of the airways. The AMCase protein was not previously thought to be involved in asthma. It was known to digest chitin, which is found in the outer wall of insects and parasites, and was not thought to be involved in inflammation.

"We found that if we block the AMCase protein with an antibody or if we use an inhibitor that prevents it from digesting chitin, we can decrease asthma-like inflammation," said senior author Jack A. Elias, M.D., the Waldemar Von Zedtwitz Professor of Medicine and Section Chief and Professor of Internal Medicine/Pulmonary and Critical Care. "Since chitin is not present in our mouse models, this protein must be acting on something other than chitin. We do not know what that is right now."

The team also found that the protein is present in the airways of human asthmatics but not in control lungs. "We are hopeful that blocking AMCase in human asthmatics will have a similar beneficial effect on the human disease," said Elias.

The inflammation seen in asthma is driven by specialized lymphocytes (white blood cells), called T helper type 2 cells. Other cell types promote different kinds of inflammation in which the AMCase protein is not made in high amounts. If this protein is blocked, it will only alter asthmatic type inflammation, but not the other types of inflammation, which are needed to fight many infections.

"We also found that interleukin-13, a protein that is well known to be important in asthmatic type inflammation is required for increased production of AMCase," said Elias. "Another protein associated with asthmatic type inflammation, interleukin-4, was not required."

"The way that blocking AMCase inhibits inflammation is unusual in that we did not prevent T helper-2 cell activation," Elias added. "We prevented production of other proteins which are needed to recruit inflammatory cells into the lung."

Other authors on the study included first author Zhou Zhu, Tao Zheng, Robert J. Homer, Yon-Keun Kim, Ning Yuan Chen, Lauren Cohn and Qutayba Hamid.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Yale Researchers Discover New Potential Asthma Therapeutic Targets Related To Parasites And Insects." ScienceDaily. ScienceDaily, 14 June 2004. <www.sciencedaily.com/releases/2004/06/040614080309.htm>.
Yale University. (2004, June 14). Yale Researchers Discover New Potential Asthma Therapeutic Targets Related To Parasites And Insects. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2004/06/040614080309.htm
Yale University. "Yale Researchers Discover New Potential Asthma Therapeutic Targets Related To Parasites And Insects." ScienceDaily. www.sciencedaily.com/releases/2004/06/040614080309.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins