Featured Research

from universities, journals, and other organizations

UCR Chemist Part Of Team Identifying New Areas Of Gene Regulation

Date:
May 7, 2005
Source:
University Of California - Riverside
Summary:
Researcher Kangling Zhang at the University of California, Riverside is part of a team that has discovered a new way that yeast governs genetic expression and repression, a finding that could be repeated in cells of other organisms.

Rendering of a Histone.
Credit: Image courtesy of University Of California - Riverside

RIVERSIDE, Calif. -- Researcher Kangling Zhang at the University of California, Riverside is part of a team that has discovered a new way that yeast governs genetic expression and repression, a finding that could be repeated in cells of other organisms.

Related Articles


Zhang, an academic coordinator at the Mass Spectrometry Facility of the Department of Chemistry at UCR, worked with Feng Xu and Michael Grunstein of the Department of Biological Chemistry at the David Geffen School of Medicine at UCLA on a paper titled Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast, which was published today in the journal Cell.

The paper focuses on observations of histones, the proteins that regulate genetic expression and form the major supporting structures housing the cell’s DNA. Histones interacting with each other form a ‘spool’ around which DNA is wrapped in the cell. Grunstein, one of the scientists in the current team, discovered in 1991 that sites of histone acetylation, a modification of the protein, play a fundamental role in the regulation of gene activation and repression.


The key findings of the current paper were the discovery of this acetylation at the core of the histone, rather than at the proteins’ ends, which are where most gene regulation is thought to take place. The team used mass spectrometry to show that acetylation at the core of the histone is associated with gene activation by attracting the protein string known as the SWI/SNI chromatin remodeling complex to the location of acetylation.

“In this paper, we used mass spectrometry to identify a novel acetylation site at the lysine 56 of yeast histone H3,” said Zhang, referring to the previously unknown location of a chemical opening to allow genetic transfers to occur.

“We found acetylation at this site near the entry-exit points of the DNA superhelix as it wraps around the nucleosome is required for recruiting the nucleosome remodeling complex SWI/SNF and so regulates gene activity,” he said.

“We show for the first time that a modification of a histone at the core of the protein, not the end, can regulate genes,” Grunstein added.

The mass spectrometry facility at the UCR’s Department of Chemistry and in the new Physical Sciences building provides super-high sensitivity for research in protein functions and in metabolic profiles of cells. The facility provides service and collaboration not limited to, protein separation, protein identification, sequencing, protein expression level quantification, as well as small molecule structural determination and metabolite identification.

Story Source:

The above story is based on materials provided by University Of California - Riverside. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Riverside. "UCR Chemist Part Of Team Identifying New Areas Of Gene Regulation." ScienceDaily. ScienceDaily, 7 May 2005. <www.sciencedaily.com/releases/2005/05/050506154737.htm>.
University Of California - Riverside. (2005, May 7). UCR Chemist Part Of Team Identifying New Areas Of Gene Regulation. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2005/05/050506154737.htm
University Of California - Riverside. "UCR Chemist Part Of Team Identifying New Areas Of Gene Regulation." ScienceDaily. www.sciencedaily.com/releases/2005/05/050506154737.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

NASA's First 3-D Printer In Space Creates Its First Object

NASA's First 3-D Printer In Space Creates Its First Object

Newsy (Nov. 26, 2014) The International Space Station is now using a proof-of-concept 3D printer to test additive printing in a weightless, isolated environment. Video provided by Newsy
Powered by NewsLook.com
Bolivian Recycling Initiative Turns Plastic Waste Into School Furniture

Bolivian Recycling Initiative Turns Plastic Waste Into School Furniture

Reuters - Innovations Video Online (Nov. 26, 2014) Innovative recycling project in La Paz separates city waste and converts plastic garbage into school furniture made from 'plastiwood'. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Blu-Ray Discs Getting Second Run As Solar Panels

Blu-Ray Discs Getting Second Run As Solar Panels

Newsy (Nov. 26, 2014) Researchers at Northwestern University are repurposing Blu-ray movies for better solar panel technology thanks to the discs' internal structures. Video provided by Newsy
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins