Featured Research

from universities, journals, and other organizations

Novel virus entry mechanism could lead to new drugs against poxviruses

Date:
April 13, 2006
Source:
Imperial College London
Summary:
Scientists working with Vaccinia virus, the smallpox vaccine, have discovered a novel mechanism that allows poxviruses to enter cells and cause infection.

Research published in the Proceedings of the National Academy of Sciences on 11 April describes how the Imperial College London team discovered the mechanism allowing Vaccinia virus to shed its outer lipid membrane and enter cells. The mechanism is unique in virology and paves the way for development of new antiviral drugs.

Related Articles


Many viruses, such as influenza, are surrounded by a single lipid membrane, or envelope, and to enter cells this membrane must be removed. Previously, all enveloped viruses were thought to shed their lipid membrane by fusion with a cell membrane which allows the virus core to be released into the cell.

In contrast, the extracellular form of Vaccinia virus has two lipid membranes, meaning a single fusion event will not release a naked virus core into the cell. The researchers found that interactions between polyanionic or negatively charged molecules on the cell surface and glycoproteins on the virus particle caused a non-fusogenic disruption of the virus outer envelope, allowing the poxvirus to enter the cell.

As well as discovering how the double membrane problem is solved, the researchers demonstrated that polyionic compounds can be used to treat poxvirus infections, even days after infection has started. Disrupting the outer membrane with polyanionic compounds exposes the virus, allowing antiviral antibodies to be more effective. The disruption of the outer membrane also limits the spread of the virus in the body.

Professor Geoffrey L. Smith FRS, from Imperial College London and a Wellcome Trust Principal Research Fellow, said: "This work has uncovered a completely novel biological process. It increases our understanding of how viruses can manipulate biological membranes and will help the development of new drugs against poxviruses, such as variola virus, the cause of smallpox."

The research team included Mansun Law, Gemma C. Carter, Kim L. Roberts, Michael Hollinshead and Geoffrey L. Smith.

The researchers have filed a patent for this discovery with Imperial Innovations, the College's spin out arm.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Novel virus entry mechanism could lead to new drugs against poxviruses." ScienceDaily. ScienceDaily, 13 April 2006. <www.sciencedaily.com/releases/2006/04/060412222250.htm>.
Imperial College London. (2006, April 13). Novel virus entry mechanism could lead to new drugs against poxviruses. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2006/04/060412222250.htm
Imperial College London. "Novel virus entry mechanism could lead to new drugs against poxviruses." ScienceDaily. www.sciencedaily.com/releases/2006/04/060412222250.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Going Ape: Sierra Leone Chimpanzees Hail Ebola Retreat

Going Ape: Sierra Leone Chimpanzees Hail Ebola Retreat

AFP (Apr. 21, 2015) As money runs out at Tacugama Chimpanzee Sanctuary in Sierra Leone, around 85 chimps are facing homelessness. The centre closed when the Ebola epidemic was ravaging the country but now that closure is beginning to look permanent. Video provided by AFP
Powered by NewsLook.com
Blue Bell Recalls All Products

Blue Bell Recalls All Products

AP (Apr. 21, 2015) Blue Bell Creameries voluntary recalled for all of its products after two samples of chocolate chip cookie dough ice cream tested positive for listeria, a potentially deadly bacteria. Blue Bell&apos;s President and CEO issued a video statement. (April 21) Video provided by AP
Powered by NewsLook.com
Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Newsy (Apr. 21, 2015) The use of complex tools has often been seen as a defining characteristic of humanity, but that notion is now in question. Video provided by Newsy
Powered by NewsLook.com
Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Newsy (Apr. 20, 2015) Five years on, the possible environmental impact of the Deepwater Horizon spill includes a sustained die-off of bottlenose dolphins, among others. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins