Featured Research

from universities, journals, and other organizations

Help For Bleeding Hearts: New Research Links A Third Protein To Blood-clotting Disorders

Date:
April 20, 2006
Source:
Rockefeller University
Summary:
A third protein has been found to play an important role in building cellular receptors that are vital for blood clotting.

Studying receptors on the surface of blood platelets, sticky cells that cause blood to clot, has given one Rockefeller researcher new insight into potential causes and treatments for certain cardiovascular diseases.

Related Articles


Barry Coller, David Rockefeller Professor and the university’s physician-in-chief, has been focusing on a rare disorder known as Glanzmann thrombasthenia, in which platelets lack one of two proteins. Together, the two proteins — αIIb and β3 — create a cellular receptor that’s involved in aggregating blood cells for coagulation; analyzing patients with the disorder previously led Coller to develop a novel therapy for heart-attack and stroke victims that targets this receptor.

In research published in the April 1 issue of Blood, Coller and Beau Mitchell, a research associate in Coller’s lab, further characterize the αIIbβ3 receptor by exploring its production and degradation. With colleagues at the Mount Sinai School of Medicine, they found that the production of the receptor, the protein complex of both αIIb and β3, is dependent on a third molecule called calnexin. Calnexin plays an important role in protein folding, and the researchers found that it not only helps form the αIIbβ3 receptor complex, but also tags improperly folded β3 proteins for destruction.

Their findings suggest that the factor that controls receptor formation is likely the calnexin cycle; if the two receptor proteins fail to form a correctly folded complex, αIIb is broken down by the cell. Coller hopes that further study of αIIbβ3 will yield more information about not just Glanzmann thrombasthenia but the synthesis of other receptors like it. These receptors, which are in the integrin superfamily, play a role in many different functions, including embryonic development, inflammation, and tumor growth and metastases, Coller says.

“Insights into rare diseases allow us to study and devise strategies for common diseases.”

Reference: Blood 107(7): 2713-2719 (April 1, 2006)


Story Source:

The above story is based on materials provided by Rockefeller University. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University. "Help For Bleeding Hearts: New Research Links A Third Protein To Blood-clotting Disorders." ScienceDaily. ScienceDaily, 20 April 2006. <www.sciencedaily.com/releases/2006/04/060420015942.htm>.
Rockefeller University. (2006, April 20). Help For Bleeding Hearts: New Research Links A Third Protein To Blood-clotting Disorders. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2006/04/060420015942.htm
Rockefeller University. "Help For Bleeding Hearts: New Research Links A Third Protein To Blood-clotting Disorders." ScienceDaily. www.sciencedaily.com/releases/2006/04/060420015942.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
This Is What It's Like To Date A Med Student

This Is What It's Like To Date A Med Student

BuzzFeed (Jan. 23, 2015) Dating is now speed-dating... or studying. Video provided by BuzzFeed
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins