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Protein Clue To Tailor-made Antibiotics

Date:
August 23, 2006
Source:
University of York
Summary:
Scientists at the University of York have made a huge leap forward in the search for "smarter" antibiotics.
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Scientists at the University of York have made a huge leap forward in the search for 'smarter' antibiotics.

A research group in the Department of Biology has made a significant advance in understanding how bacteria use proteins to conduct a type of biological warfare.

Bacteria like E. coli frequently try to kill each other when resources are scarce using protein antibiotics called colicins, which are potent toxins.

The research led by Professor Colin Kleanthous has discovered a critical element in the mode of action of a class of colicins (so-called DNases) that kill cells by destroying their DNA.

Though most proteins have a folded structure, DNase colicins are only partially so. The scientists have found that the unfolded part of DNase colicin structure makes its way into an unsuspecting bacterium and blocks a key process that lowers the cell's defences and allows the toxin to enter.

The research, which was supported by the Wellcome Trust and the Biotechnology and Biological Sciences Research Council, is published in the latest edition of the Proceedings of the National Academy of Sciences (PNAS).

Professor Kleanthous said: "Antibiotic resistance is on the increase throughout the world. Understanding how bacteria have evolved to kill each other with protein toxins might offer ways of constructing new, tailor-made antibiotics that target particular microorganisms."

Researchers are now trying to establish what it is about this blocking mechanism (which they've christened 'competitive recruitment') that lowers the cells' defences toward the colicin.


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The above post is reprinted from materials provided by University of York. Note: Materials may be edited for content and length.


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University of York. "Protein Clue To Tailor-made Antibiotics." ScienceDaily. ScienceDaily, 23 August 2006. <www.sciencedaily.com/releases/2006/08/060822150830.htm>.
University of York. (2006, August 23). Protein Clue To Tailor-made Antibiotics. ScienceDaily. Retrieved July 7, 2015 from www.sciencedaily.com/releases/2006/08/060822150830.htm
University of York. "Protein Clue To Tailor-made Antibiotics." ScienceDaily. www.sciencedaily.com/releases/2006/08/060822150830.htm (accessed July 7, 2015).

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