Featured Research

from universities, journals, and other organizations

Risks Of Gastrointestinal Ulcers Linked To Aspirin Use Might Outweigh Its Benefits For The Heart

Date:
September 22, 2006
Source:
BioMed Central
Summary:
Doctors should consider whether patients are at high risk of stomach ulcers before prescribing aspirin treatment. A study published today in the open access journal BMC Medicine reveals that low-dose aspirin treatment may be responsible for one extra case of gastrointestinal complications, which include ulcer bleeding or perforation, in every 50 aspirin users per year in susceptible groups, such as older men with a history of peptic ulcer.

Doctors should consider whether patients are at high risk of stomach ulcers before prescribing aspirin treatment.

Related Articles


A study published today in the open access journal BMC Medicine reveals that low-dose aspirin treatment may be responsible for one extra case of gastrointestinal complications, which include ulcer bleeding or perforation, in every 50 aspirin users per year in susceptible groups, such as older men with a history of peptic ulcer. The authors conclude that for some patients taking aspirin to reduce their risk of heart attack, the risk of gastrointestinal complications might outweigh the cardioprotective effects of the drug.

Sonia Hernández-Díaz and Luis García Rodríguez analysed two anonymous databases of patient information, the General Practice Research Database in the UK and the Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria in Spain, to characterise patients taking low-dose aspirin as a preventive measure against heart attack, in terms of major gastrointestinal risk factors.

Risk factors for upper gastrointestinal tract complications include advanced age, male sex, prior ulcer history and use of other non-steroidal anti-inflammatory drugs (NSAIDs). The researchers then estimated the excess gastrointestinal risk caused by aspirin use in patients with and without these risk factors.

Hernández-Díaz and García Rodríguez find that 88% of aspirin users are over 60 and that 52-54% of them are male. From 3.8% to 5.9% of them have a history of gastrointestinal ulcer. Across all risk groups, aspirin use is responsible for an extra 5-6 cases of upper gastrointestinal tract complications per 1,000 aspirin users per year. This excess risk is larger in populations that are at high risk of gastrointestinal complications, such as older men or patients with a history of peptic ulcer.

The authors estimate that aspirin use might be responsible for 20 extra cases per 1,000 aspirin users per year in men older than 70 with a past history of peptic ulcer. On the other hand, the excess risk is smaller in populations that are at low risk of gastrointestinal complications.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Risks Of Gastrointestinal Ulcers Linked To Aspirin Use Might Outweigh Its Benefits For The Heart." ScienceDaily. ScienceDaily, 22 September 2006. <www.sciencedaily.com/releases/2006/09/060920093207.htm>.
BioMed Central. (2006, September 22). Risks Of Gastrointestinal Ulcers Linked To Aspirin Use Might Outweigh Its Benefits For The Heart. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2006/09/060920093207.htm
BioMed Central. "Risks Of Gastrointestinal Ulcers Linked To Aspirin Use Might Outweigh Its Benefits For The Heart." ScienceDaily. www.sciencedaily.com/releases/2006/09/060920093207.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) — Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) — While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins