Featured Research

from universities, journals, and other organizations

Antioxidants Decrease Disease In Fruit Fly Model Of Alzheimer's Disease

Date:
December 15, 2006
Source:
Journal of Clinical Investigation
Summary:
Alzheimer's disease (AD) is a neurodegenerative disorder in which brain cells damaged by naturally occurring chemicals known as reactive oxygen species have been observed. Whether this oxidative damage causes neurodegeneration or is a consequence of it has not been previously determined. A study now indicates that oxidative damage contributes to neurodegeneration in a Drosophila model of disorders such as AD, suggesting that targeting antioxidant pathways might provide a new approach for treating individuals with AD.

Alzheimer's disease (AD) is one of a number of neurodegenerative disorders in which brain cells damaged by naturally occurring chemicals known as reactive oxygen species (ROS) have been observed. However, whether this oxidative damage causes neurodegeneration or is a consequence of it has not been previously determined.

Related Articles


A study appearing online on December 14, in advance of publication in the January print issue of the Journal of Clinical Investigation, indicates that oxidative damage is a factor contributing to neurodegeneration in a Drosophila model of neurodegenerative disorders such as AD.

Mel Feany and colleagues from Brigham and Women's Hospital and Harvard Medical School assessed neuron cell death in Drosophila expressing a neurodegenerative disease--associated form of the human protein tau. The number of dying neurons was increased if these insects were also genetically modified to have high levels of ROS.

By contrast, if the insects were treated with the antioxidant vitamin E they had decreased numbers of dying neurons. This demonstration that oxidative stress contributes to neurodegeneration in this model of AD suggests that targeting antioxidant pathways might provide a new approach for treating individuals with AD and other related neurodegenerative disorders.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Antioxidants Decrease Disease In Fruit Fly Model Of Alzheimer's Disease." ScienceDaily. ScienceDaily, 15 December 2006. <www.sciencedaily.com/releases/2006/12/061215091114.htm>.
Journal of Clinical Investigation. (2006, December 15). Antioxidants Decrease Disease In Fruit Fly Model Of Alzheimer's Disease. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/12/061215091114.htm
Journal of Clinical Investigation. "Antioxidants Decrease Disease In Fruit Fly Model Of Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2006/12/061215091114.htm (accessed October 24, 2014).

Share This



More Mind & Brain News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins