Featured Research

from universities, journals, and other organizations

Why Don't Mothers' Bodies Reject Their Fetus?

Date:
April 23, 2007
Source:
Journal of Clinical Investigation
Summary:
The immune system is designed to attack anything that is not the body's own tissues, such as pathogens and genetically nonidentical organ transplants, so why does the maternal immune system not attack a developing fetus?

The immune system is designed to attack anything that is not the body's own tissues, such as pathogens and genetically nonidentical organ transplants, so why does the maternal immune system not attack a developing fetus? Several answers to this question are provided by a new study of mice from researchers at New York University School of Medicine.

In the study, in the May print issue of the Journal of Clinical Investigation, Adrian Erlebacher and colleagues show that when maternal immune cells known as T cells interact with fetal cells they can't "see" proteins that only their fetus expresses. By contrast, the same maternal T cells were able to "see" the fetal proteins when other maternal immune cells began picking up the fetal proteins around mid-gestation.

However, this did not result in the T cells being primed to attack the fetus, rather, it induced the T cells to die. Surprisingly, even when the T cells were isolated from the female mice and exposed to the fetal proteins in vitro, under conditions that normally stimulate T cell activation, the maternal T cells did not become activated. This study therefore describes three reasons why maternal T cells do not attack a developing fetus and the authors suggest that immune-mediated early pregnancy loss might occur if maternal T cells become able to "see" fetal proteins when they interact with fetal cells.

Article: Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Why Don't Mothers' Bodies Reject Their Fetus?." ScienceDaily. ScienceDaily, 23 April 2007. <www.sciencedaily.com/releases/2007/04/070421212932.htm>.
Journal of Clinical Investigation. (2007, April 23). Why Don't Mothers' Bodies Reject Their Fetus?. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2007/04/070421212932.htm
Journal of Clinical Investigation. "Why Don't Mothers' Bodies Reject Their Fetus?." ScienceDaily. www.sciencedaily.com/releases/2007/04/070421212932.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins