Featured Research

from universities, journals, and other organizations

Skin Biology And Pathology -- Without The Need To Use Live Animals

Date:
May 11, 2007
Source:
Universitat Autonoma de Barcelona
Summary:
Researchers have developed an artificial cellular model which faithfully reproduces the characteristics of dog's skin and which will allow, therefore, the carrying out of various lines of research related to skin biology and pathology without the need to use live animals.

Researchers at the UAB and UNIVET, in cooperation with Affinity Petcare, have developed an artificial canine skin model, very similar to normal skin, which is useful for research and which represents an alternative to the use of animals in research. The model allows the study of those illnesses which most often affect dogs' skin without the need to use animals.
Credit: Image courtesy of Universitat Autonoma de Barcelona

Researchers at UNIVET, a spin-off of the Universitat Autònoma de Barcelona, in cooperation with the animal nutrition company Affinity Petcare, have developed an artificial cellular model which faithfully reproduces the characteristics of dog's skin and which will allow, therefore, the carrying out of various lines of research related to skin biology and pathology without the need to use live animals.

The basic structure of skin consists of an external layer, the epidermis, and an internal layer, the dermis, separated by a basal membrane. A study of the interactions between the cell populations of the various layers is of vital importance for skin biology, but these interactions cannot be investigated adequately by means of conventional cell cultures.

Researchers at the UAB and UNIVET, in cooperation with Affinity Petcare, have developed an artificial canine skin model, very similar to normal skin, which is useful for research and which represents an alternative to the use of animals in research. The model allows the study of those illnesses which most often affect dogs' skin without the need to use animals.

To develop this model, cells from the epidermis (keratocytes) and the dermis (fibroblasts) from samples of healthy dogs were used. The dermis cells, inserted into a collagen matrix (a very common protein in skin and joints), were used as a support for the epidermis cells, which were grown on its surface and were kept in growth conditions exposed to air. The cells proliferated forming the various layers of the epidermis.

The model develops a morphological structure similar to that of canine skin. Additionally, the expression of the dermis and epidermis proteins follows the same pattern of expression as that of normal canine skin, even forming a basal membrane, which also maintains the characteristics of conventional skin.

 


Story Source:

The above story is based on materials provided by Universitat Autonoma de Barcelona. Note: Materials may be edited for content and length.


Cite This Page:

Universitat Autonoma de Barcelona. "Skin Biology And Pathology -- Without The Need To Use Live Animals." ScienceDaily. ScienceDaily, 11 May 2007. <www.sciencedaily.com/releases/2007/05/070510123730.htm>.
Universitat Autonoma de Barcelona. (2007, May 11). Skin Biology And Pathology -- Without The Need To Use Live Animals. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2007/05/070510123730.htm
Universitat Autonoma de Barcelona. "Skin Biology And Pathology -- Without The Need To Use Live Animals." ScienceDaily. www.sciencedaily.com/releases/2007/05/070510123730.htm (accessed April 20, 2014).

Share This



More Plants & Animals News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) — Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
Man Claims He Found Loch Ness Monster With... Apple Maps?

Man Claims He Found Loch Ness Monster With... Apple Maps?

Newsy (Apr. 18, 2014) — Andy Dixon showed the Daily Mail a screenshot of what he believes to be the mythical beast swimming just below the lake's surface. Video provided by Newsy
Powered by NewsLook.com
First Ever 'Female Penis' Discovered In Animal Kingdom

First Ever 'Female Penis' Discovered In Animal Kingdom

Newsy (Apr. 18, 2014) — Not only are these newly discovered bugs' sex organs reversed, but they also mate for up to 70 hours. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins