Featured Research

from universities, journals, and other organizations

New, More Effective Treatment For Toxic Shock Syndrome

Date:
May 22, 2007
Source:
University of Minnesota
Summary:
Researchers have developed a new therapeutic that neutralizes toxic shock syndrome more effectively than other treatments, study suggests. Toxic Shock Syndrome is a rare, life-threatening bacterial infection that can cause multi-organ failure and death.

Researchers at the University of Minnesota and the University of Illinois at Urbana-Champaign have developed a new therapeutic that neutralizes Toxic Shock Syndrome (TSS) more effectively than other treatments.

Related Articles


Toxic Shock Syndrome is a rare, life-threatening bacterial infection that can cause multi-organ failure and death. A major cause of the disease is a superantigen called staphylococcal enterotoxin B (SEB), which is produced by Staphylococcus aureus bacteria. SEB binds to T-lymphocytes in the body causing the release of cytokines, resulting in the dramatic blood pressure drop seen in TSS.

Currently, TSS can be treated with antibiotics to kill the bacteria and antibodies to neutralize SEB. But, as published in the May 21, 2007 issue of Nature Medicine, scientists have engineered a new high-affinity molecule known as V-beta which blocks SEB's ability to bind to T-cells. By targeting the early stages of disease onset, V-beta neutralizes SEB at a rate 2000 times more effective than typical antibody treatment.

"The development and efficacy of V-beta in animal models is a very significant advancement in infectious disease treatment," said Patrick Schlievert, Ph.D., co-author of the paper and professor of microbiology at the University of Minnesota Medical School. "It represents an easily produced, potential treatment for diseases caused by SEB and other superantigens associated with TSS."

Schlievert and colleague Marnie Peterson, Pharm.D., Ph.D., co-author and assistant professor at the University of Minnesota College of Pharmacy Department of Experimental and Clinical Pharmacology, studied the effects of V-beta on SEB in rabbit models. The treatment of rabbits with SEB was successful when given V-beta following onset of disease, after SEB had caused a high fever and symptoms of TSS, and after rabbits had been exposed to SEB on a continuous basis.

"Not only is SEB a major cause of Toxic Shock Syndrome, it also is considered a potential biological weapon," explained Schlievert. "With that in mind, the small amount of V-beta needed for SEB neutralization makes this a truly significant discovery and useful therapy."

Approximately 3 out of every 100,000 people will get TSS annually. In addition, nearly 35,000 people die every year from post influenza infection, which is often caused by TSS or pneumonia. Symptoms of TSS include high fever, low blood pressure, vomiting and diarrhea, and a rash that looks similar to sunburn. While the infection often occurs in menstruating women and is associated with the use of superabsorbent tampons and contraceptive items, it can also affect men, children and postmenopausal women, particularly following respiratory viral infections. Other risk factors include skin wounds and surgery.

This study was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University of Minnesota. "New, More Effective Treatment For Toxic Shock Syndrome." ScienceDaily. ScienceDaily, 22 May 2007. <www.sciencedaily.com/releases/2007/05/070521140852.htm>.
University of Minnesota. (2007, May 22). New, More Effective Treatment For Toxic Shock Syndrome. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2007/05/070521140852.htm
University of Minnesota. "New, More Effective Treatment For Toxic Shock Syndrome." ScienceDaily. www.sciencedaily.com/releases/2007/05/070521140852.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins