Featured Research

from universities, journals, and other organizations

Mouse Model Of Autism Spectrum Disorders Developed

Date:
September 10, 2007
Source:
Howard Hughes Medical Institute
Summary:
Researchers have genetically engineered mice that harbor the same genetic mutation found in some people with autism and Asperger syndrome. Mice with this mutation show a similar type of social impairment and cognitive enhancement as the type seen in some people with autism spectrum disorders (ASDs). ASDs are enigmatic cognitive disorders that impair a patient's social interactions, but do not necessarily limit their intelligence.

Howard Hughes Medical Institute researchers have genetically engineered mice that harbor the same genetic mutation found in some people with autism and Asperger syndrome.

Mice with this mutation show a similar type of social impairment and cognitive enhancement as the type seen in some people with autism spectrum disorders (ASDs). ASDs are enigmatic cognitive disorders that impair a patient's social interactions, but do not necessarily limit their intelligence.

The scientists said the mice they developed may represent an important advance in modeling autism spectrum disorders in mice and offer researchers a new tool for understanding how specific defects in neural development may lead to autism.

Howard Hughes Medical Institute investigator Thomas Südhof and his colleagues at the University of Texas Southwestern Medical Center published their findings September 6, 2007, in Science Express, which provides electronic publication of selected Science papers ahead of print.

The researchers engineered mice that have a single mutation in the gene for a protein called neuroligin-3. This protein functions as a cell adhesion molecule in synapses, the junctions that connect neurons in the brain and allow them to communicate with each other. Synapses are essential to all brain activities, such as perception, behavior, memory, and thinking. Südhof said that the neuroligin-3 mutation that his team recapitulated in the mice has been identified in some people with genetic conditions known as autism spectrum disorders (ASDs). Mutations in proteins that interact with neuroligin-3 have also been detected in some people with ASDs.

Proper function of the brain's neuronal networks depends on a delicate balance between excitatory and inhibitory electrophysiological signaling among neurons. Südhof and his colleagues found that this balance was disrupted in the mutant mice, which also showed an increase in the signaling of inhibitory neurotransmitters. In contrast, they found that knocking out the neurologin-3 gene entirely produced no such imbalance.

The most striking behavioral abnormality they observed in the mutant mice was an impaired ability to interact socially with other mice. However, the animals showed enhanced spatial learning and memory--and were more able than normal mice to learn and to remember the location of a platform submerged in murky water.

"This combination of electrophysiological and behavioral effects is quite remarkable," said Südhof. "It was also significant that these mice did not exhibit any other impairment of nervous system function -- there was no abnormal locomotor activity or motor coordination, for example. This was a selective change, with social impairment on the one hand, yet cognitive enhancement on the other."

Südhof said the mutant mice he and his colleagues developed potentially offer major advantages over other mouse models of ASDs. "In mouse models of autism that I am aware of, the autistic symptoms are only one minor part of the overall disease," he said. "For example, autistic symptoms are only one component of mouse models of Fragile X syndrome.

"What sets this mouse model apart is that the mouse shows highly selective social deficits and memory enhancement, but as far as we can tell, no other pathologies. This makes it a potentially useful model for a subset of people with ASDs with just such characteristics," he said.

Südhof his colleagues will use the mouse model to ask additional questions about the role that neuroligin proteins play in neural function and in ASDs. "We can also use these mice to study how these autistic symptoms--loss of social ability and enhanced memory--arise from the increase in inhibitory neurotransmission," he said. "The key to understanding this mechanism will be in finding out what parts of the brain are responsible for these characteristics. And with this mouse model, we can identify precisely where the mutation acts in the brain."


Story Source:

The above story is based on materials provided by Howard Hughes Medical Institute. Note: Materials may be edited for content and length.


Cite This Page:

Howard Hughes Medical Institute. "Mouse Model Of Autism Spectrum Disorders Developed." ScienceDaily. ScienceDaily, 10 September 2007. <www.sciencedaily.com/releases/2007/09/070906140744.htm>.
Howard Hughes Medical Institute. (2007, September 10). Mouse Model Of Autism Spectrum Disorders Developed. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2007/09/070906140744.htm
Howard Hughes Medical Institute. "Mouse Model Of Autism Spectrum Disorders Developed." ScienceDaily. www.sciencedaily.com/releases/2007/09/070906140744.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Captive Dolphin Gives Birth

Captive Dolphin Gives Birth

Reuters - Light News Video Online (Oct. 20, 2014) — SeaWorld in San Diego welcomes a new bottlenose dolphin, the second calf for 13-year-old female, Sadie. Rough Cut. (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
White Rhino's Death In Kenya Means Just 6 Are Left

White Rhino's Death In Kenya Means Just 6 Are Left

Newsy (Oct. 20, 2014) — Suni, a rare northern white rhino at Ol Pejeta Conservancy, died Friday. This, as many media have pointed out, leaves people fearing extinction. Video provided by Newsy
Powered by NewsLook.com
Fish Fossil Shows First-Ever Sex Was Done Side By Side

Fish Fossil Shows First-Ever Sex Was Done Side By Side

Newsy (Oct. 19, 2014) — A 380-million-year-old fish may be the first creature to have copulative sex - and it was side by side with arms linked, like square dancers. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins