Featured Research

from universities, journals, and other organizations

Genetics Of MLL Leukemogenesis

Date:
October 18, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists have identified the gene Meis1 as a critical player in the establishment of leukemia stem cells, and the development of MLL leukemia.

In the November 1st issue of Genes & Development, Dr. Michael Cleary (Stanford University School of Medicine) and colleagues identify the gene Meis1 as a critical player in the establishment of leukemia stem cells, and the development of MLL leukemia.

Related Articles


Mixed lineage leukemia (MLL) is a distinctive type of leukemia -- distinguished from the more prevalent acute lymphoblastic leukemia (ALL) by the presence of a break and rearrangement of chromosome number 11. The design of effective therapies to combat MLL leukemia depends upon the understanding of the unique genetic signature that underlies this disease.

This chromosomal translocation that characterizes MLL activates the histone methyltranferase enzyme called MLL, inducing it to turn-on downstream gene targets that transform blood progenitor cells into leukemia stem cells (LSCs).

While some of the downstream targets of MLL are known (Hox genes, for example), the genetic changes that are sufficient to drive MLL leukomogeneis have remained elusive. Dr. Cleary and colleagues focused their work on another group of proteins that are mis-expressed in MLL leukemias: the TALE (three-amino-acid loop extension) class of proteins.

The researchers found that one gene in particular -- called Meis1 -- is required for leukemia stem cell maintenance. In fact, the researchers showed that Meis1 regulates many important biological properties of the disease including differentiation arrest, cycling activity, in vivo progression and self-renewal of LSCs.

Dr. Cleary is confident that "The critical role of Meis1 and other TALE class proteins in MLL leukemia stem cells provides a promising avenue for future studies to design more selective therapies for this poor prognosis subtype of leukemia."


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Genetics Of MLL Leukemogenesis." ScienceDaily. ScienceDaily, 18 October 2007. <www.sciencedaily.com/releases/2007/10/071016181218.htm>.
Cold Spring Harbor Laboratory. (2007, October 18). Genetics Of MLL Leukemogenesis. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2007/10/071016181218.htm
Cold Spring Harbor Laboratory. "Genetics Of MLL Leukemogenesis." ScienceDaily. www.sciencedaily.com/releases/2007/10/071016181218.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins