Featured Research

from universities, journals, and other organizations

Protein Found That Helps Nerve Cells Cheat Death Without Unwanted Side Effects

Date:
February 13, 2008
Source:
Journal of Clinical Investigation
Summary:
The prototypical member of the VEGF family of proteins, VEGF, protects cells in the nervous system from death and degeneration. However, its clinical utility in this regard is limited, because it also induces blood vessel growth, a process known as angiogenesis. However, a new study has revealed that another VEGF family member, VEGF-B, does not have such limitations as it acts as a potent inhibitor of murine retinal cell death while exerting minimal angiogenic effects.

The prototypical member of the VEGF family of proteins, VEGF, has recently been shown to protect cells in the nervous system from death and degeneration. However, its clinical utility in this regard is limited, because it also induces blood vessel growth, a process known as angiogenesis.

Related Articles


In a new study, Xuri Li and colleagues at the National Institutes of Health, Bethesda, have revealed that the VEGF family member VEGF-B acts as a potent inhibitor of murine retinal cell death while exerting minimal angiogenic effects.

In addition to inhibiting expression of cell-death--related genes, VEGF-B was shown to reduce the death of murine retinal cells in culture models of cellular injury and in mouse models of ocular neurodegenerative disorders.

Furthermore, VEGF-B treatment inhibited brain cell death in a mouse model of stroke.

As the concentration of VEGF-B required for retinal protection did not lead to angiogenesis in the mouse retina, the authors concluded that VEGF-B might provide a new therapeutic option for the treatment of neurodegenerative disease.

Journal reference: VEGF-B inhibits apoptosis via VEGFR-1--mediated suppression of the expression of BH3-only protein genes in mice and rats. Journal of Clinical Investigation. February 8, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Protein Found That Helps Nerve Cells Cheat Death Without Unwanted Side Effects." ScienceDaily. ScienceDaily, 13 February 2008. <www.sciencedaily.com/releases/2008/02/080207172343.htm>.
Journal of Clinical Investigation. (2008, February 13). Protein Found That Helps Nerve Cells Cheat Death Without Unwanted Side Effects. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2008/02/080207172343.htm
Journal of Clinical Investigation. "Protein Found That Helps Nerve Cells Cheat Death Without Unwanted Side Effects." ScienceDaily. www.sciencedaily.com/releases/2008/02/080207172343.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Brawling Pandas Are Violently Adorable

Brawling Pandas Are Violently Adorable

Buzz60 (Jan. 29, 2015) Video of pandas play fighting at the Chengdu Research Base in China will make your day. Mara Montalbano (@maramontalbano) shows us. Video provided by Buzz60
Powered by NewsLook.com
Why Researchers Say We Should Cut Back On Biofuels

Why Researchers Say We Should Cut Back On Biofuels

Newsy (Jan. 29, 2015) Biofuels aren&apos;t the best alternative to fossil fuels, according to a new report. In fact, they&apos;re quite a bad one. Video provided by Newsy
Powered by NewsLook.com
3-D Printed Wheelchair Helps Two-Legged Dog Learn to Run

3-D Printed Wheelchair Helps Two-Legged Dog Learn to Run

Buzz60 (Jan. 29, 2015) 3-D printing helps another two-legged dog run around with his four-legged friends. Jen Markham (@jenmarkham) has the adorable video. Video provided by Buzz60
Powered by NewsLook.com
Dogs Bring on So Many Different Emotions in Their Human Best Friends

Dogs Bring on So Many Different Emotions in Their Human Best Friends

RightThisMinute (Jan. 28, 2015) From new-puppy happy tears to helpful-grocery-carrying-dog laughter, our four-legged best friends can make us feel the entire spectrum of emotions. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins