Featured Research

from universities, journals, and other organizations

'Super Yeasts' Produce 300 Times More Protein Than Previously Possible

Date:
May 13, 2008
Source:
American Chemical Society
Summary:
Researchers in California report development of a new kind of genetically modified yeast cell that produces complex proteins up to 300 times more than possible in the past. These "super yeasts" could help boost production and lower prices for a new generation of protein-based drugs that show promise for fighting diabetes, obesity, and other diseases, the researchers suggest.

Researchers in California report development of a new kind of genetically modified yeast cell that produces complex proteins up to 300 times more than possible in the past. These "super yeasts" could help boost production and lower prices for a new generation of protein-based drugs that show promise for fighting diabetes, obesity, and other diseases, the researchers suggest.

Related Articles


In their report, Lei Wang and Qian Wang explain that the yeasts are intended for speeding production of proteins containing so-called "unnatural amino acids" (UAAs). Living things normally use the same basic set of 20 amino acids to make proteins. Scientists have made additional amino acids, the UAAs, which show promise for building new proteins with a broad range of medical and industrial applications. However, researchers had had difficulty in efficiently incorporating these UAAs into useful protein products.

Wang and Wang are reporting a solution to that problem. They inserted parts of the simple but highly efficient protein-making machinery of E. coli bacteria into the advanced but inefficient protein-making machinery of yeast cells. The result was a best-of-both world's creation: A genetically-engineered yeast cell that produces complex proteins containing UAAs at levels 300 times higher than normal yeast cells.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Qian Wang, Lei Wang. New Methods Enabling Efficient Incorporation of Unnatural Amino Acids in Yeast. Journal of the American Chemical Society, 2008; 130 (19): 6066 DOI: 10.1021/ja800894n

Cite This Page:

American Chemical Society. "'Super Yeasts' Produce 300 Times More Protein Than Previously Possible." ScienceDaily. ScienceDaily, 13 May 2008. <www.sciencedaily.com/releases/2008/05/080512092318.htm>.
American Chemical Society. (2008, May 13). 'Super Yeasts' Produce 300 Times More Protein Than Previously Possible. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2008/05/080512092318.htm
American Chemical Society. "'Super Yeasts' Produce 300 Times More Protein Than Previously Possible." ScienceDaily. www.sciencedaily.com/releases/2008/05/080512092318.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com
Rover Finds More Clues About Possible Life On Mars

Rover Finds More Clues About Possible Life On Mars

Newsy (Dec. 17, 2014) NASA's Curiosity rover detected methane on Mars and organic compounds on the surface, but it doesn't quite prove there was life ... yet. Video provided by Newsy
Powered by NewsLook.com
Ivory Trade Boom Swamps Law Efforts

Ivory Trade Boom Swamps Law Efforts

Reuters - Business Video Online (Dec. 17, 2014) Demand for ivory has claimed the lives of tens of thousands of African elephants and now a conservation report says the illegal trade is overwhelming efforts to enforce the law. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins