Featured Research

from universities, journals, and other organizations

Enzyme Key To 'Sister Act' That Maintains Genome Stability

Date:
July 14, 2008
Source:
Baylor College of Medicine
Summary:
Keeping the genome stable is a "sister act" of matched chromatids -- the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle.

Keeping the genome stable is a "sister act" of matched chromatids -- the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle.

Maintaining the chromatids in their sister pairs rests with Eco1, a kind of enzyme known as an acetyltransferase. Now researchers at Baylor College of Medicine, in a collaboration of two laboratories, have shown that Eco1 and its human homologue maintain sister chromatid cohesion and thus genome stability through a chemical process called acetylation that affects Smc3, one of the key components of the cohesion protein complex.

A report on their work appears in the current online issue of the journal Molecular Cell.

This activity is critical to maintaining the stability of the cell's genome and its survival, said Dr. Jun Qin, associate professor of biochemistry and molecular biology and molecular and cellular biology at BCM and a senior author of the report.

"If a cell lacks this acetyltransferase activity, it's dead," said Dr. Xuewen Pan, assistant professor of biochemistry and molecular biology and molecular and human genetics at BCM and also a senior author.

"This is critical for genome stability, cell growth and organism survival," said Qin.

"The collaboration in this work was important," he said. His laboratory carried out the work in human cells, and Pan's did the work in yeast.

"We pooled the resources of our two laboratories and took advantage of the power of the genetics in yeast and the power of proteomics and cell biology in the human. If a single labor had worked on this project, we would not have as complete a story," Qin said.

Others who took part in this work include Jinglan Zhang, Xiaomin Shi, Yehua Li, , Junlin Jia, Zhiwei Huang, Tao Yang, Xiaoyong Fu, Sung Yun Jung, Yi Wang and Pumin Zhang , all of BCM and Beom-Jun Kim and Seon-Tae Kim of Sungkyunkwan University School of Medicine in Korea.

Funding for this work came from the National Institutes of Health and the Korea Research Foundation Grant from the Korean Government.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College of Medicine. "Enzyme Key To 'Sister Act' That Maintains Genome Stability." ScienceDaily. ScienceDaily, 14 July 2008. <www.sciencedaily.com/releases/2008/07/080710120505.htm>.
Baylor College of Medicine. (2008, July 14). Enzyme Key To 'Sister Act' That Maintains Genome Stability. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2008/07/080710120505.htm
Baylor College of Medicine. "Enzyme Key To 'Sister Act' That Maintains Genome Stability." ScienceDaily. www.sciencedaily.com/releases/2008/07/080710120505.htm (accessed April 19, 2014).

Share This



More Plants & Animals News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
Man Claims He Found Loch Ness Monster With... Apple Maps?

Man Claims He Found Loch Ness Monster With... Apple Maps?

Newsy (Apr. 18, 2014) Andy Dixon showed the Daily Mail a screenshot of what he believes to be the mythical beast swimming just below the lake's surface. Video provided by Newsy
Powered by NewsLook.com
First Ever 'Female Penis' Discovered In Animal Kingdom

First Ever 'Female Penis' Discovered In Animal Kingdom

Newsy (Apr. 18, 2014) Not only are these newly discovered bugs' sex organs reversed, but they also mate for up to 70 hours. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins