Featured Research

from universities, journals, and other organizations

Enzyme Key To 'Sister Act' That Maintains Genome Stability

Date:
July 14, 2008
Source:
Baylor College of Medicine
Summary:
Keeping the genome stable is a "sister act" of matched chromatids -- the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle.

Keeping the genome stable is a "sister act" of matched chromatids -- the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle.

Maintaining the chromatids in their sister pairs rests with Eco1, a kind of enzyme known as an acetyltransferase. Now researchers at Baylor College of Medicine, in a collaboration of two laboratories, have shown that Eco1 and its human homologue maintain sister chromatid cohesion and thus genome stability through a chemical process called acetylation that affects Smc3, one of the key components of the cohesion protein complex.

A report on their work appears in the current online issue of the journal Molecular Cell.

This activity is critical to maintaining the stability of the cell's genome and its survival, said Dr. Jun Qin, associate professor of biochemistry and molecular biology and molecular and cellular biology at BCM and a senior author of the report.

"If a cell lacks this acetyltransferase activity, it's dead," said Dr. Xuewen Pan, assistant professor of biochemistry and molecular biology and molecular and human genetics at BCM and also a senior author.

"This is critical for genome stability, cell growth and organism survival," said Qin.

"The collaboration in this work was important," he said. His laboratory carried out the work in human cells, and Pan's did the work in yeast.

"We pooled the resources of our two laboratories and took advantage of the power of the genetics in yeast and the power of proteomics and cell biology in the human. If a single labor had worked on this project, we would not have as complete a story," Qin said.

Others who took part in this work include Jinglan Zhang, Xiaomin Shi, Yehua Li, , Junlin Jia, Zhiwei Huang, Tao Yang, Xiaoyong Fu, Sung Yun Jung, Yi Wang and Pumin Zhang , all of BCM and Beom-Jun Kim and Seon-Tae Kim of Sungkyunkwan University School of Medicine in Korea.

Funding for this work came from the National Institutes of Health and the Korea Research Foundation Grant from the Korean Government.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College of Medicine. "Enzyme Key To 'Sister Act' That Maintains Genome Stability." ScienceDaily. ScienceDaily, 14 July 2008. <www.sciencedaily.com/releases/2008/07/080710120505.htm>.
Baylor College of Medicine. (2008, July 14). Enzyme Key To 'Sister Act' That Maintains Genome Stability. ScienceDaily. Retrieved September 14, 2014 from www.sciencedaily.com/releases/2008/07/080710120505.htm
Baylor College of Medicine. "Enzyme Key To 'Sister Act' That Maintains Genome Stability." ScienceDaily. www.sciencedaily.com/releases/2008/07/080710120505.htm (accessed September 14, 2014).

Share This



More Plants & Animals News

Sunday, September 14, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Conservationists Face Uphill PR Battle With New Shark Rules

Conservationists Face Uphill PR Battle With New Shark Rules

Newsy (Sep. 14, 2014) — New conservation measures for shark fishing face an uphill PR battle in the fight to slow shark extinction. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) — A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) — In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com
Spinosaurus Could Be First Semi-Aquatic Dinosaur

Spinosaurus Could Be First Semi-Aquatic Dinosaur

Newsy (Sep. 11, 2014) — New research has shown that the Spinosaurus, the largest carnivorous dinosaur, might have been just as well suited for life in the water as on land. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins