Featured Research

from universities, journals, and other organizations

Vaccine Against Multiple Sclerosis? Mouse Experiment Yields Promising Results

Date:
December 3, 2008
Source:
University Hospital Heidelberg
Summary:
Researchers in Germany have succeeded in vaccinating mice with specially treated, autologous immune cells and preventing them from developing encephalitis, which is similar to multiple sclerosis in humans.

Some 80,000 people in Germany suffer from multiple sclerosis – their immune system attacks and destroys healthy nerve tissue. Researchers at the Heidelberg University Hospital and the German Cancer Research Center in Heidelberg have succeeded in vaccinating mice with specially treated, autologous immune cells and preventing them from developing encephalitis, which is similar to multiple sclerosis in humans.

Related Articles


A protein of the nervous system, that is the target of the harmful immune reaction in multiple sclerosis, was placed on the surface of the cells; the cells were treated with an agent that suppresses immune defense.

The Heidelberg researchers have published their results, initially online, in the Proceedings of the National Academy of Sciences USA.

The team around Professor Dr. Peter Terness is working in the Department of Transplantation Immunology (Director: Professor Dr. Gerhard Opelz) of the Institute of Immunology at the Heidelberg University Hospital. Professor Terness and his colleagues work primarily on developing methods to prevent rejection of  donor organs without impairing the immune system.

Vaccine developed from transplant research

“The vaccine against multiple sclerosis works on the same principle,” explains Professor Terness. “We have to teach the immune system not to fight the donor organ, or in this case its own nerve cells, as a foreign body.”

In the course of their research on organ rejection, the scientists successfully treated immune cells (known as dendritic cells) of a donor animal with the chemotherapeutic agent mitomycin and injected them into the organ recipient before transplantation – the modified cells were not attacked. The immune system of the transplant recipient subsequently accepted the tissue of the donor animal as well. The results were published in “Transplantation” in 2007.

Treated cells suppress the immune response

Subsequently, Professor Terness’s team used this procedure to suppress the harmful immune response in multiple sclerosis  – in cooperation with Dr. Thilo Oelert from the Department of Molecular Immunology at the German Cancer Research Center they loaded immune cells from mice with a self protein from the nervous system, treated them with mitomycin, and reinjected them into the animals. Afterwards, experimental autoimmune encephalitis – the equivalent of multiple sclerosis in humans – could no longer be induced in these mice; they were resistant.

“The treated cells express the target protein and simultaneously suppress the immune response. In this manner, the immune cells become accustomed to the protein and do not attack it later, even without the inhibitor,” explains Professor Terness.

The researchers now want to study whether this method is also effective for treating already-existing multiple sclerosis. They will use animal experiments to study whether the vaccine with treated autologous cells has not only a preventive effect, but a therapeutic effect as well.


Story Source:

The above story is based on materials provided by University Hospital Heidelberg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peter Terness, Thilo Oelert, Sandra Ehser, Jing Jing Chuang, Imad Lahdou, Christian Kleist, Florian Velten, Gόnter J. Hδmmerling, Bernd Arnold and Gerhard Opelz. Mitomycin C-treated dendritic cells inactivate autoreactive T cells: Toward the development of a tolerogenic vaccine in autoimmune diseases. Proc Natl Acad Sci USA, 2008; DOI: 10.1073/pnas.0807185105

Cite This Page:

University Hospital Heidelberg. "Vaccine Against Multiple Sclerosis? Mouse Experiment Yields Promising Results." ScienceDaily. ScienceDaily, 3 December 2008. <www.sciencedaily.com/releases/2008/12/081201105851.htm>.
University Hospital Heidelberg. (2008, December 3). Vaccine Against Multiple Sclerosis? Mouse Experiment Yields Promising Results. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2008/12/081201105851.htm
University Hospital Heidelberg. "Vaccine Against Multiple Sclerosis? Mouse Experiment Yields Promising Results." ScienceDaily. www.sciencedaily.com/releases/2008/12/081201105851.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) — Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins