Featured Research

from universities, journals, and other organizations

'Birth Control' For Centrioles

Date:
January 27, 2009
Source:
Rockefeller University Press
Summary:
Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication.

Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication.

Related Articles


Centrioles start reproducing themselves during G1 or S phase. What prevents the organelles from xeroxing themselves again and again has puzzled researchers for more than a decade. The process could be analogous to the mechanism for controlling DNA replication. There, a licensing factor preps the DNA for duplication. During DNA synthesis, the factor gets tagged with ubiquitin molecules that prompt its destruction, thus preventing another round of copying.

To determine whether a similar mechanism keeps centrioles in check, Rogers et al. blocked Drosophila cells' production of different proteins that combine to form a ubiquitin-adding complex. Loss of one of these proteins, Slimb, allowed cells to fashion extra centrioles, the researchers found.

Slimb's target, the team showed, is the enzyme Plk4, which sports a Slimb-binding motif. Plk4 levels on the centrioles peaked during mitosis, and the enzyme vanished from the organelles by S phase. However, a mutant form of Plk4 that Slimb couldn't latch onto clung to the centrioles throughout the cell cycle and caused their over-duplication.

Plk4 serves as a licensing factor for centriole copying, Rogers et al. suggest. During mitosis, it sets the stage for the next cell division by phosphorylating an unidentified protein (or proteins) that will later instigate centriole duplication. Slimb and its protein partners then ubiquitinate Plk4, so that no enzyme remains on the centrioles by the time they are ready for copying. Thus, the organelles are duplicated once only. Tumor cells often bypass the limit on centriole duplication, and the work suggests that drugs to restrict the organelles' replication might hold promise as cancer treatments.

Journal reference: Rogers, G.C., et al. 2009. J. Cell Biol. doi:10.1083/jcb.200808049.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Cite This Page:

Rockefeller University Press. "'Birth Control' For Centrioles." ScienceDaily. ScienceDaily, 27 January 2009. <www.sciencedaily.com/releases/2009/01/090126100640.htm>.
Rockefeller University Press. (2009, January 27). 'Birth Control' For Centrioles. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2009/01/090126100640.htm
Rockefeller University Press. "'Birth Control' For Centrioles." ScienceDaily. www.sciencedaily.com/releases/2009/01/090126100640.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Amazon Keeps Its Green Thanks To The Sahara Desert

The Amazon Keeps Its Green Thanks To The Sahara Desert

Newsy (Feb. 25, 2015) Satellite data shows the Amazon rainforest supports its lush flora with a little help from Sahara Desert dust. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com
Fox With Horrifying Injury Rescued and Released Back Into the Wild

Fox With Horrifying Injury Rescued and Released Back Into the Wild

RightThisMinute (Feb. 25, 2015) This wounded fox knew what she was doing when she wandered into the yard of a nature photographer. The photographer got "Scamp" immediately in the hands of Wildlife Aid and she was released back into the wild in no time. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins