Featured Research

from universities, journals, and other organizations

Vaccine Protects Against 1918 Influenza Strain

Date:
February 25, 2009
Source:
American Society for Microbiology
Summary:
Researchers have developed a vaccine that appears to protect against the 1918 "Spanish" influenza virus. Using a mammalian expression system they created a virus-like particle (VLP) that mimics the 1918 influenza virus, prompting the immune system to develop protective antibodies.

Researchers have developed a vaccine that appears to protect against the 1918 "Spanish" influenza virus. Using a mammalian expression system they created a virus-like particle (VLP) that mimics the 1918 influenza virus, prompting the immune system to develop protective antibodies.

This is the first report describing the use of a 1918 VLP vaccine expressed and purified from mammalian cells. The results show that a non-replicating VLP is an effective influenza vaccine against the 1918 virus.

Scientists from the University of Pittsburgh and the Centers for Disease Control and Prevention administered the VLP vaccine to mice and ferrets, which were completely protected from a lethal challenge with the 1918 virus.

VLPs are small packages of artificially produced viral protein. They are assembled either spontaneously using high concentrations of viral protein, or by embedding the protein in a lipid membrane during protein synthesis. When encountered by an immune cell, a VLP looks like a real virus particle, because it is coated in viral protein (the antigen). However, because a VLP lacks DNA or RNA, it is not infectious.

VLP vaccines are made using cell expression systems. This genetic engineering approach, utilizing either mammalian cells or yeast, is often found in the production of vaccines. Cell culture systems are closely controlled, and can be scaled up relatively easily. In contrast, egg-based systems which provide the main source of current influenza vaccines rely on large supplies of fertilised chicken eggs for vaccine production, and are more difficult to control.

This research was presented February 24, 2009 at the ASM Biodefense and Emerging Diseases Research Meeting in Baltimore, MD.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Vaccine Protects Against 1918 Influenza Strain." ScienceDaily. ScienceDaily, 25 February 2009. <www.sciencedaily.com/releases/2009/02/090224154900.htm>.
American Society for Microbiology. (2009, February 25). Vaccine Protects Against 1918 Influenza Strain. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/02/090224154900.htm
American Society for Microbiology. "Vaccine Protects Against 1918 Influenza Strain." ScienceDaily. www.sciencedaily.com/releases/2009/02/090224154900.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins