Featured Research

from universities, journals, and other organizations

New Test For Deadly Fungal Infection In Patients With Damaged Immune Systems

Date:
April 5, 2009
Source:
Society for General Microbiology
Summary:
A quicker, cheaper and more accurate test for deadly Aspergillus fumigatus fungal infections in patients with damaged or suppressed immune systems was recently developed.

A quicker, cheaper and more accurate test for deadly Aspergillus fumigatus fungal infections in patients with damaged or suppressed immune systems was described April 2 at the Society for General Microbiology meeting in Harrogate, by Dr Christopher Thornton from the University of Exeter, UK.

Fungal infections are a significant cause of death in patients whose immune systems are suppressed, for example those undergoing bone marrow transplantation or chemotherapy. Infection by breathing in the spores of the fungus Aspergillus fumigatus can cause invasive aspergillosis (IA) that can have a fatality rate approaching 90%. IA is very difficult to detect; doctors need to take tissue samples to see if the fungus is growing in the body.

As this is often not possible in very sick patients, tests that detect signature molecules of the fungus in patient's serum are used. These existing tests are costly, and require expertise and sophisticated laboratory facilities to run. They also cannot distinguish between molecules from the Aspergillus fungus and similar molecules from antibiotics and foodstuffs, and even certain bacteria.

Dr Thornton and colleagues have developed a test for IA using technology similar to that used in home pregnancy tests. The test uses a monoclonal antibody that binds to a glycoprotein antigen secreted specifically by Aspergillus species. It does not give a reaction with any other clinically important fungi. It only takes 15 minutes to perform, making it quicker and less costly than conventional laboratory-based tests.

"Because our test is user-friendly it can be used to diagnose IA at the 'point-of-care' for patients, said Dr Thornton, "it can be used to provide routine monitoring of patients at high-risk for the disease, such as bone marrow transplant recipients and leukaemia patients. We are currently working with a multinational clinical diagnostics company to develop a commercial version of the device."


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "New Test For Deadly Fungal Infection In Patients With Damaged Immune Systems." ScienceDaily. ScienceDaily, 5 April 2009. <www.sciencedaily.com/releases/2009/04/090401200437.htm>.
Society for General Microbiology. (2009, April 5). New Test For Deadly Fungal Infection In Patients With Damaged Immune Systems. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/04/090401200437.htm
Society for General Microbiology. "New Test For Deadly Fungal Infection In Patients With Damaged Immune Systems." ScienceDaily. www.sciencedaily.com/releases/2009/04/090401200437.htm (accessed July 30, 2014).

Share This




More Plants & Animals News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Otters Enjoy Water Slides at Japan Zoo

Raw: Otters Enjoy Water Slides at Japan Zoo

AP (July 30, 2014) River otters were hitting the water slides to beat the summer heatwave on Wednesday at Ichikawa City's Zoological and Botanical Garden. (July 30) Video provided by AP
Powered by NewsLook.com
In Virginia, the Rise of a New Space Coast

In Virginia, the Rise of a New Space Coast

AP (July 30, 2014) Every summer, tourists make the pilgrimage to Chincoteague Island, Va. to see wild ponies cross the Assateague Channel. But, it's the rockets sending to supplies to the International Space Station that are making this a year-round destination. (July 30) Video provided by AP
Powered by NewsLook.com
Rodents Rampant in Gardens Around Louvre

Rodents Rampant in Gardens Around Louvre

AP (July 29, 2014) Food scraps and other items left on the grounds by picnickers brings unwelcome visitors to the grounds of the world famous and popular Louvre Museum in Paris. (July 29) Video provided by AP
Powered by NewsLook.com
Jane Goodall Warns Great Apes Face Extinction

Jane Goodall Warns Great Apes Face Extinction

AFP (July 29, 2014) The world's great apes face extinction within decades, renowned chimpanzee expert Jane Goodall warned Tuesday in a call to arms to ensure man's closest relatives are not wiped out. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins