Featured Research

from universities, journals, and other organizations

Phosphate Balance In Higher Organisms Elucidated

Date:
May 17, 2009
Source:
Ruhr-Universitaet-Bochum
Summary:
Polyphosphate chains play an important physiological role in many organisms, for example to ensure cell growth even under deficiency conditions. Chemists and biochemists have now gained insight into the basic data on the formation mechanism of polyphosphate chains. The scientists have been able to identify the first x-ray structure of the enzyme responsible for the biosynthesis of polyphosphates in highly developed organisms (eukaryotes) and to distinguish the basic biochemical processes.

Polyphosphate chains play an important physiological role in many organisms, for example to ensure cell growth even under deficiency conditions. To date, there is however little data available on their formation and mode of function.

Related Articles


Chemists and biochemists at the Ruhr University, working in collaboration with research scientists at the European Molecular Biology Laboratory in Heidelberg and the University of Lausanne, have now gained insight into the basic data on the formation mechanism of polyphosphate chains.

The scientists have been able to identify the first x-ray structure of the enzyme responsible for the biosynthesis of polyphosphates in highly developed organisms (eukaryotes) and to distinguish the basic biochemical processes. The molecular catalytic processes can be accurately described based on the data obtained. This knowledge constitutes the foundation for further targeted research into the role of polyphosphates. The scientists have published their results in the current edition of the journal Science.

The enzyme investigated - VTC (vacuolar transporter chaperone) - makes use of the universal “energy carrier” ATP (adenosine triphosphate) within cells for the gradual synthesis of phosphate chains. A depot, which the organism can resort to under stress conditions, is thus created. Using structure-biological and biophysical methods, the scientists were able to show which molecular tools the enzyme uses for the reorganization of the phosphates from the source into the depot.

Prof. Christian Herrmann (Physical Chemistry I) explained that the structure of the chain-shaped depot substance and its simultaneous transport in a cellular subunit with the aid of a tunnel-shaped protein structure is of particular interest. The VTC enzyme is part of a large protein complex that reaches the cell via an inner membrane. Its characterization is a milestone for research into ATP-dependent membrane processes.


Story Source:

The above story is based on materials provided by Ruhr-Universitaet-Bochum. Note: Materials may be edited for content and length.


Cite This Page:

Ruhr-Universitaet-Bochum. "Phosphate Balance In Higher Organisms Elucidated." ScienceDaily. ScienceDaily, 17 May 2009. <www.sciencedaily.com/releases/2009/05/090512093551.htm>.
Ruhr-Universitaet-Bochum. (2009, May 17). Phosphate Balance In Higher Organisms Elucidated. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2009/05/090512093551.htm
Ruhr-Universitaet-Bochum. "Phosphate Balance In Higher Organisms Elucidated." ScienceDaily. www.sciencedaily.com/releases/2009/05/090512093551.htm (accessed October 26, 2014).

Share This



More Plants & Animals News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins