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DNA: Cohesin Jigsaw Begins To Fit

Date:
May 18, 2009
Source:
Genome Biology
Summary:
The essential chromosomal protein complex cohesin has crucial roles in sister chromatid cohesion, DNA repair and transcriptional regulation. Despite its conserved function, cohesin's disparate association patterns in different organisms did not quite add up. New research works towards completing the cohesin puzzle, reconciling some of these differences.

The essential chromosomal protein complex cohesin has crucial roles in sister chromatid cohesion, DNA repair and transcriptional regulation. Despite its conserved function, cohesin's disparate association patterns in different organisms did not quite add up. New research works towards completing the cohesin puzzle, reconciling some of these differences.

Christine Schmidt, Neil Brookes and Frank Uhlmann working together at the Cancer Research UK London Research Institute, performed high-resolution analysis of cohesin binding patterns along fission yeast chromosomes.

The authors' findings suggest that features thought to differentiate cohesin between organisms actually collectively define the overall behaviour of fission yeast cohesin. In fact cohesin's mechanisms of action might be much more similar between organisms than previously thought.

Earlier studies investigated cohesin's chromosomal binding sites in different model organisms, including Drosophila and budding yeast. Despite its conserved function in DNA repair and mitosis, no common rule had emerged that defined these sites.

"Our findings suggest that features that were thought to differentiate cohesin behaviour between organisms collectively define the overall behaviour of fission yeast cohesin", writes Uhlmann. "Apparent differences between organisms could reflect an emphasis on different aspects, rather than different principles, of cohesin behaviour."

Cohesin complexes have a central role in cell division, mediating the association between sister chromosomes. Cohesin forms large proteinaceous rings, and is thought to bind to and holds sister chromatids together in a topological embrace.


Story Source:

The above story is based on materials provided by Genome Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christine K Schmidt, Neil Brookes and Frank Uhlmann. Conserved features of cohesin binding along fission yeast chromosomes. Genome Biology, (in press)

Cite This Page:

Genome Biology. "DNA: Cohesin Jigsaw Begins To Fit." ScienceDaily. ScienceDaily, 18 May 2009. <www.sciencedaily.com/releases/2009/05/090518213943.htm>.
Genome Biology. (2009, May 18). DNA: Cohesin Jigsaw Begins To Fit. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2009/05/090518213943.htm
Genome Biology. "DNA: Cohesin Jigsaw Begins To Fit." ScienceDaily. www.sciencedaily.com/releases/2009/05/090518213943.htm (accessed April 24, 2014).

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