Featured Research

from universities, journals, and other organizations

Scientists reveal key structure from Ebola virus

Date:
December 9, 2009
Source:
Scripps Research Institute
Summary:
Scientists have determined the structure of a critical protein from the Ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of those infected.

Scientists at The Scripps Research Institute have determined the structure of a critical protein from the Ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of those infected.

Related Articles


Described in the advance, online Early Edition of the journal Proceedings of the National Academy of Sciences (PNAS), the research reveals how a key component of the Ebola virus, called VP35, blocks the human immune system, allowing the virus uncontrolled replication. The structure represents a major step forward in understanding how the deadly virus works, and may be useful in the development of potential treatments for those infected.

"After infection, the virus and immune system are in a race," said Erica Ollmann Saphire, Ph.D., associate professor at Scripps Research, who led the three-year effort to solve the structure. "If the virus can hide its molecular signatures, it can suppress immune responses and replicate unchecked. This new understanding of the mechanism that Ebola virus uses to evade the immune system opens the door for developing drug therapies."

A signature of Ebola virus infection is the presence of the virus's double-stranded RNA, which, when detected by immune system proteins, triggers a full immune response. The new research describes how the VP35 protein of the Ebola virus masks the double-stranded RNA to prevent the immune response.

The protein structure, determined by X-ray crystallography, showed that VP35 binds another copy of itself, and the pair cooperatively masks the RNA ends. Christopher Kimberlin, the first author of this study, explained that this assembly is unusual because each member of the pair binds the RNA in a different way, revealing that VP35 has two unique strategies for masking viral signatures. Importantly, the interface between the two VP35 molecules provides a new target for drugs that would stop Ebola virus infection and allow the immune system to clear the infection. Additional RNA binding, small angle X-ray scattering, and deuterium exchange mass spectrometry experiments confirm the cooperative function of these molecules for immunosuppression.

There is currently no cure for Ebola hemorrhagic fever. The virus is spread when people come into contact with the bodily fluids of an infected person or animal. Most die from a combination of dehydration, massive bleeding, and shock. There is currently no vaccine or drug therapy for Ebola infection, but the findings of this study may lead to new treatments.

Support for the research was provided by grants from the National Institutes of Health, a Career Award from the Burroughs Wellcome Fund, and The Skaggs Institute for Chemical Biology.


Story Source:

The above story is based on materials provided by Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher Kimberlin, Zachary Bornholdt, Ian Macrae, Erica Ollmann Saphire, Sheng Li and Virgil Woods, Jr. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proceedings of the National Academy of Sciences, (in press)

Cite This Page:

Scripps Research Institute. "Scientists reveal key structure from Ebola virus." ScienceDaily. ScienceDaily, 9 December 2009. <www.sciencedaily.com/releases/2009/12/091208170913.htm>.
Scripps Research Institute. (2009, December 9). Scientists reveal key structure from Ebola virus. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2009/12/091208170913.htm
Scripps Research Institute. "Scientists reveal key structure from Ebola virus." ScienceDaily. www.sciencedaily.com/releases/2009/12/091208170913.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins