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New insights into the 3-D organization of the human genome

Date:
March 26, 2010
Source:
Public Library of Science
Summary:
Insights into the genomics of the human nucleolus have been revealed in a study by researchers in Germany and Spain. The research sheds new light on the functional organization of human genetic material.
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Insights into the genomics of the human nucleolus have been revealed in a study by researchers from the University of Regensburg and the Ludwig Maximilians University in Germany and the Centro de Investigación Príncipe Felipe in Spain. The research, published March 26 in the open-access journal PLoS Genetics, sheds new light on the functional organization of human genetic material.

One major challenge of the post-genomic era is to understand how the genome is organized inside the cell's nucleus to fulfill the dynamics and regulation of DNA access to regulatory factors. Previous studies on the nuclear architecture of the cell suggest that the three-dimensional structure of genomic information is non-random. However, few discrete genomic loci have been analyzed for their spatial location, prompting the current study.

The researchers, led by Attila Németh and Gernot Längst, examined the DNA network of the nucleolus, the nucleus' largest sub-compartment, using sequencing, microarray analysis, and single-cell analysis. The work resulted in a high-resolution sequence map of this nuclear structure, detailing the position of the several thousand genes and non-coding sequences that form the nucleolus within the three-dimensional space of the nucleus.

"The results help us understand how nuclear information is packaged into functional compartments of the nucleus," say the authors. At the same time, the authors emphasise that this research was confined to just two cell types, and that further studies are needed to address the conservation of these packaging mechanisms during evolution, and to monitor the developmental dynamics of three-dimensional genome organization.


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The above post is reprinted from materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Németh A, Conesa A, Santoyo-Lopez J, Medina I, Montaner D, et al. Initial Genomics of the Human Nucleolus. PLoS Genetics, 2010; 6 (3): e1000889 DOI: 10.1371/journal.pgen.1000889

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Public Library of Science. "New insights into the 3-D organization of the human genome." ScienceDaily. ScienceDaily, 26 March 2010. <www.sciencedaily.com/releases/2010/03/100325214541.htm>.
Public Library of Science. (2010, March 26). New insights into the 3-D organization of the human genome. ScienceDaily. Retrieved July 5, 2015 from www.sciencedaily.com/releases/2010/03/100325214541.htm
Public Library of Science. "New insights into the 3-D organization of the human genome." ScienceDaily. www.sciencedaily.com/releases/2010/03/100325214541.htm (accessed July 5, 2015).

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